2-trifluoromethylbenzimidazoles

Abstract

Abstract BENZIMIDAZOLE COMPOUNDS OF THE FORMULA: 2-X,4-R1,5-R2,6-R3,7-R4-BENZIMIDAZOLE AND SALTS THEREOF, WHERE IN THE ABOVE FORMULA R1, R2, R3 AND R4 MAY BE THE SAME OR DIFFERENT AND ARE SELECTED FROM THE GROUP COMPRISING HYDROGEN, ALKYL (FOR EXAMPLE 1-6 CARBON ATOMS SUCH AS METHYL, ETHYL OR PROPYL), HYDROXY, ALKOXY (FOR EXAMPLE METHOXY, ETHOXY OR BUTOXY), NITRO, HALOGEN (FOR EXAMPLE CHLORO, BROMO OR FLUORO), PSEDUOHALOGEN (FOR EXAMPLE CYANO, THIOCYANO, ISOTHIOCYANO OR AZIDO), SUBSTITUTED ALKYL (FOR EXAMPLE, TRIFLUOROMETHYL, CHLOROMETHYL, BROMETHYL, TRICHLOROMETHYL, HYDROXYMETHYL, 2-CHLOREETHYL, 2-HYDROXYETHYL OR 2-METHOXYETHYL), CARBOXY, CARBOXY ESTER, CARBOXY AMIDE, N-SUBSTITUTED CARBOXY AMIDE, N-DISUBSTITUTED CARBOXY AMIDE, AMINO (FOR EXAMPLE METHYLAMINO, DIMETHYLAMINO, ACETYLAMINO, TRIFLUOROACETYLAMINO, BENZENESULPHONAMIDO, PARATOLUENESULPHONAMIDO, METHANESULPHONAMIDO), THIOL, ALKYLTHIOL, AND OXYGENATED DERIVATIVES THEREOF (FOR EXAMPLE -SOR5 OR -SO2R5 WHERE R5 IS ALKYL), SULPHONIC ACID AND ESTERS AND AMIDES THEREOF, SUBSTITUTED AMIDE (FOR EXAMPLE, PHENYLSULPHAMYL, ETHYLSULPHAMYL, CHLOROETHYLSULPHAMYL), RADICALS AND WHERE X IS TRIFLUOROMETHYL OR PENTAFLUOROETHYL, POSSESS PHYSIOLOGICAL ACTIVITY AND ARE USEFUL IN THE FORMULATION OF PHYSIOLOGICALLY ACTIVE COMPOSITIONS.

Inventors

• 👤 D Burton
• 👤 A Lambie
• 👤 G Newbold

Bibliographic Details