1-(m-halo-p-amino-phenyl)-4-aminotert.butanols-(1)and salts thereof

Abstract

Abstract (-R4)-)BENZENE COMPOUNDS OF THE FOMRULA WHEREIN HAL IS CHLORINE OR BROMINE, R1 IS HYDROGEN, CHLORINE OR BROMINE, R2 IS HYDROGEN ALKYL, ALKYENYL, DIALKYLAMINO-ALKYL, CYCLOALKYL, PHENYL, ARALKYL OR ADAMANTYL, R2 IS ALKYL, ALKENYL, DIALKYLAMINO-ALKYL, CYCLOALKYL, PHENYL, ARALKYL OR ADAMANNTYL, R2 AND R3, TOGETHER WITH EACH OTHER AND THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED, ARE PYRROLIDINO, PIPERIDINO, PIPERAZINO, MORPHOLINO, HEXAMETHYLENEIMINO OR CAMPHIDINO, WHERE EACH OF THESE MAY OPTIONALLY HAVE ONE OR MORE HYDROXY, ALKOXY, PHENYL OR LOWER ALKYL SUBSTITUENTS ATTACHED THERETO, AND R4 IS ALLYL, CYCLOALKYL, CYCLOAKENYL, NORBORNYL, PHENYL, ARALKYL, NAPTHTHYL, PRYDYL OR THIENYL, WHERE SAID CYCLOALKYL MAY OPTIONALY HAVE ONE OR MORE HYDROXYL, ALKYL, ALKOXY, ALKYLTHIO, TRIFULOROMETHYL, PHENYL OR PHENOXY SUBSTITUENTS ATTACHED THEREOT, AND SAID PHENYL MAY OPTIONALLY HAVE ONE OR MORE FLUORO, CHLORO OR BROMO SUBSTITUENTS ATTACHED THERETO, AND THEIR NON-TOXIC, PHARMOCOLOGICALLY ACCEPTABLE ACID ADDITION SALTS; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AN SEDATIVES, ANTI-EMETICS, STOMACH ULCLER-INHIBTORS AND CNS-STIMULANTS IN WARM-BLOODED ANIMALS. 1-R1,2-(H2N-),3-(HAL-),5-((-R2-R3-)>N-CH2-CH2-CH2-C(-OH)

Inventors

• 👤 H Pieper
• 👤 G Kruger
• 👤 J Kahling
• 👤 K Noll
• 👤 J Keck

Bibliographic Details