Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
Abstract
Abstract 3''-O-ACYL AND 3''-O-ACYL-5-ACYL-DERIVATIVES OF THE SALTS OF O-2,2''-ANHYDRO-1-(B-ARABINOFURANOSYL)-CYTOSINES AND METHODS OF PREPARING SUCH COMPOUNDS. THE COMPOUNDS ARE FURTHER CHARACTERIZED IN THAT EACH COMPOUND HAS A HIGHER ACYL GROUP AT THE 3''-O-POSITION AND/OR THE 5''-OPOSITION. THE COMPOUNDS CAN BE PREPARED BY PREPARED BY REACTING THE CORRESPONDING 1-(B-D-RIBOFURANOSYL) CYTOSINE WITH A SUITABLE A-ACYLOXYCL HALIDE HAVING THE DESIRED ACYL SUBSITUTED. THE COMPOUNDS ARE ISOLATED AND RECOVERED AS PHARMACEUTICALLY ACCEPTABLE SALTS AND EXHIBITS ANTI-VIRAL, CYTOTOXIC AND ANTI-NEOPLASTIC ACTIVITY, AND THIS ARE USEFUL FOR THE TREATMENT OF MAMMALS WHERE SUCH AGENTS ARE INDICATED. THE COMPOUNDS ARE ALSO USEFUL AS INTERMEDIATES FOR PREPARING THE CORRESPONDING 1-(B-D-DARABINOFURANOZYL)CYTOSINES.
Inventors
- 👤 J Moffatt
- 👤 A Russell
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-02-11 | 1977-08-13 | 1978-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-02-11 | 1981-08-13 | 1982-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-02-11 | 1985-08-13 | 1986-02-12 | $7700.00 | Window Closed / Lapsed |