Sulphonic acid esters,their production and compositions of and uses therefor
Abstract
Abstract SULPHONIC ACID ESTERS OF THE FORMULA: WHEREIN X, Y AND Z ARE AS ABOVE DEFINED; MN+ IS A CATION WHICH FORMS A SPARINGLY SOLUBLE IODIDE; AND N IS 1 OR 2. THESE COMPOUNDS ARE USEFUL FOR THEIR CYTOSTATIC ACTIVITY AGAINST TRANSPLANTED LYMPHATIC LEUKAEMIA L 1210 IN MICE. (Y-C(-X)(-Z)-SO3(-))N M(+)N WHEREIN A, A'' AND B ARE AS ABOVE DEFINED, WITH A SULPHONATE OF THE FORMULA: I-CH2-CH2-CO-N(-A)-B-N(-A'')-CO-CH2-CH2-I WHEREIN A AND A'' ARE THE SAME OR DIFFERENT AND EACH IS HYDROGEN OR AN ALIPHATIC MOIETY; B IS A BIFUNCTIONAL ALIPHATIC MOIETY; AND X, Y AND Z ARE THE SAME OR DIFFERENT AND EACH IS HYDROGEN, HALOGEN, NITRILE, PSEUDO-HALOGEN OR METHYLSULPHONYL, ARE PRODUCED BY REACTING A DI-IODO COMPOUND OF THE FORMULA: C(-X)(-Z)-Y Y-C(-X)(-Z)-SO3-(CH2)2-CO-N(-A)-B-N(-A'')-CO-(CH2)2-O3S-
Inventors
- 👤 R Bierling
- 👤 D Steinhoff
- 👤 A Senning
- 👤 H Buchholt
- 👤 G Trossmann
Bibliographic Details
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