Tripeptide
Abstract
Abstract THE TRIPEPTIDE (O-R'')SER - (O-R")TYR - GLY-OR WHEREIN R IS HYDROGEN, METHYL OR BENZYL AND R'' AND R" ARE PROTECTIVE GROUPS ON THE HYDROXY GROUP OF THE TYROSYL AND SERYL MOIETIIES IS A VALUABLE INTERMEDIATE FOR THE MANUFACTURE OF THE GONADOTROPIN-RELEASING HOROMONE. IT CAN EASILY BE REACRED TO FORM THE NA-BLOCKED FRAGMENT TRP(O-R'')SER-(O-R")TYR-GLY-OH WHICH REACTS WITH LEU(N-R"'')ARG-PRO-GLY-NH2 CARRYING A PROTECTIVE GROUP (R"'') IN THE ARG MOIETY. TO THE CORRESPONDING OCTAPEPTIDE FROM WHICH GN-RH CAN BE OBTAINED BY REMOVING THE BLOCKING GROUP OF TRP, REACTING THE DEPROTECTED OCTAPEPTIDE WITH N-PROTECTED HISTIDINE, REMOVING THE PROTECTIV GROUP OF THE LATTER, SUBSEQUENTLY REACTING THE NONAPEPTIDE WITH N-PROTECTED PYROGLUTAMIC ACID AND REMOVING ALL THE PROTECTIVE GROUPS, LEAVING ONLY THE UNSUBSTITUTED DECAPEPTIDE CHAIN PYRO-GLU-HIS-TRP-SER-TYR-GLY-LEU-ARG-PROGLY-NH2.
Inventors
- 👤 G Flouret
- 👤 J Cole
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-01-21 | 1977-07-23 | 1978-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-01-21 | 1981-07-23 | 1982-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-01-21 | 1985-07-23 | 1986-01-22 | $7700.00 | Window Closed / Lapsed |