4-substituted coumarins
Abstract
Abstract 4-SUBSTITUTED COUMARINS HAVING THE FOLLOWING STRUCTURAL FORMULA ARE DISCLOSED: 2-(O=),4-R1,5,6-((-Z-O)(-R2)(-R3))-2H-PYRAN WHEREIN R1 IS (METHYLSULFINYL)METHYL, (METHYLSULFONYL) METHYL, ACETYL(METHYLTHIO)METHYL, DIMETHOXYMETHYL, FORMYL, HYDROXYMETHYL, (ARYLIMINO)METHYL, (ARYLAMINO) METHYL OR (OXIMINO)METHYL; Z IS AN AROMATIC OR HETEROAROMATIC NUCLEUS; R2 AND R3 ARE HYDROGEN, HALOGEN, ALKYL, ARALKYL, ARYL, ALKOXY, ACYLAMINO, OR HYDROXY. THESE COMPOUNDS ARE PREPARED BY THE FOLLOWING REACTION SCHEME: (=CH(-OH)-Z-)(-R3)(-R4)>C-CO-CH2-SO-CH3 --PH3P=CHCO2R4---> 2-(O=),4-(CH3-SO-CH2-),5,6-((-Z-)(-R2)(-R3))-2H-PYRAN WHEREIN R4 IS LOWER ALKYL. THE 4 - ((METHYLSULFINYL)METHYL)COUMARINS ARE THEN CONVERTED TO OTHER 4-SUBSTITUTED COUMARINS OF THIS INVENTION. THE COMPOUNDS OF THIS INVENTION ARE USEFUL AS GASTRIC ANTISCRETORY AGENTS ARE INDICATED IN CONDITIONS SUCH AS GASTRIC HYPERACIDITY.
Inventors
- 👤 Strandtmann M Von
- 👤 J Shavel
Bibliographic Details
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