N-oxide of double stranded rna

Abstract

Abstract N-OXIDES OF NATURAL DOUBLE-STANDED RIBONUCLIEC ACIDS AND SALTS THEREOF, WHICH ARE THEMSELVES DOUBLE-STRANDED, PREPARED BY REACTING DOUBLE-STRANDED RIBONUCLEIC ACIDS WITH HYDROGEN PERIOXIDE OR A PERACID, ARE DESCRIBED. THE NEW RNA DERIVATIVES ARE INTERFERON INDUCERS AND/OR HAVE ANTIVIRAL ACTIVITY AND ARE LESS TOXIC THAN THE PRENT RNA''S. NATURAL RNA''S HAVE EDENINE, CYTOSINE, URACIL AND GUANINE BASES LINKED TO REPEATING RIBOSE/PHOSPHATE BACKBONE UNITS AND DIFFERENT DEGREES OF OXIDATION OF THE BASES CAN BE CARRIED TO PRODUCE A VARIETY OF NEW N-OXIDE DERIVATIVES. THE CONVERSION TO SINGLE-STRANDED MATERIAL IS AVOIDED BY LIMITING THE EXTENT OF OXIDATION AND LEAVING SOME UNOXIDIZED BASE SITES. FORMULATION INTO AEROSOLS, INJECTIBLES AND TOPICALS IS DESCRIBED.

Inventors

• 👤 M Harnden

Bibliographic Details