(4-substituted)4-(methylsulfinyl)methylcarbostyrils

Abstract

Abstract COMPOUNDS OF THE FOLLOWING FORMULA: 1-R4,2-(O=),4-R1,R2,R3-1,2-DIHYDROQUINOLINE WHEREIN R1 IS (METHYLSULFINYL)METHYL, DIMETHOXYMETHYL, ACETY(METHYLTHIO)METHYL, FORMYL OR HYDROXYMETHYL; R2 AND R3 ARE HYDROGEN, HALOGEN, LOWER ALKYL, ARALKYL, ARYL, LOWER ALKOXY, ACYLAMINO, HYDROXY OR TAKEN TOGETHER R2 AND R3 FORM ANOTHER AROMATIC RING, AND R4 IS HYDROGEN OR METHYL, ARE DESCRIBED. THE COMPOUNDS OF THIS INVENTION ARE USEFUL FOR THE TREATMENT OF ALLERGIC CONDITIONS. THE ABOVE COMPOUNDS, WHERE R1 IS (METHYLSULFINYL) METHYL, ARE PREPARED AS FOLLOWS: 1-(R4-NH-),2-(CH3-SO-CH2-CO-),R2,R3-BENZENE AND (PH)3- P=CH-COO-CH2-CH3 -> 1-R4,2-(O=),4-(CH3-SO-CH2-),R2, R3-1,2-DIHYDROQUINOLINE WHEN R1 IS OTHER THAN (METHYLSULFINYL)METHYL, THEY ARE PREPARED BY TREATING THE (METHYLSULFINYL)METHYL SUBSTITUTED CARBOSTYRILS WITH ACETIC ANHYDRIDE AS SET FORTH IN THE BODY OF THE SPECIFICATION. THESE COMPOUNDS ARE USEFUL IN PROVIDING SYMPTOMATIC RELIEF OF ALLERGIC CONDITIONS SUCH AS BRONCHIAL ASTHMA.

Inventors

• 👤 Strandtmann M Von
• 👤 D Connor

Bibliographic Details