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US3759974A
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Substituted 4-cyano-4-phenyl-aminocyclohexanes
Assignee: Abbott GmbH and Co KG
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Filing: 1969-09-09
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Granted: 1973-09-18
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Expires: 1989-09-09
Abstract
Abstract Basically substituted 4-cyano-4-phenyl-aminocyclo-hexanes of the general formula WHEREIN A, B, C, A'', B'', C'' are each hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy; R is hydrogen or lower alkyl; and Alk is straight or branched chain lower alkylene or hydroxy lower alkylene, their acid addition salts and their pharmaceutical composition. The compounds and compositions are valuable blood pressure depressants, which also exhibit spasmolytic, neuroleptic and coronary dilating properties.
Inventors
- 👤 H Treiber
- 👤 F Zimmermann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:06
CPC Classifications
C; C07; C07C; C07C253/00; C07C253/30; C07C255/00; C07C255/45; C07C255/46; C07C2601/00; C07C2601/12; C07C2601/14
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
9 words
The compound of claim 1 wherein R is methyl.
Claim 2
Dependent Claim
9 words
The compound of claim 1 wherein R is hydrogen.
Claim 3
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 1.
Claim 4
Dependent Claim
63 words
The compound of claim 1 wherein in the 4-position the A, B, C-substituted phenyl group is selected from the following: 4-phenyl-; 4-(2-methylphenyl)-; 4-(3-trifluoromethylphenyl)-; 4-(3, 4-dimethoxyphenyl)-; 4-(3,4-diethoxyphenyl) and 4-(4-chloro-phenyl); while R is hydrogen or methyl and Alk is ethylene, and the A'', B'', C''-substituted phenyl is selected from the following: 3,4-di- or trimethoxy- or ethoxyphenyl or phenyl substituted by a chloro or a trifluoro-methyl.
Claim 5
Dependent Claim
12 words
The pharmaceutically acceptable acid addition salts of a compound of claim 5.
Claim 6
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 5.
Claim 7
Dependent Claim
9 words
The compound of claim 5 wherein R is methyl.
Claim 8
Dependent Claim
54 words
The compound of claim 1 wherein A is hydrogen, chlorine, trifluoromethyl, or methyl, B is hydrogen, methoxy or ethoxy, C is hydrogen, chlorine, methoxy or ethoxy, A'' is hydrogen, trifluoromethyl, methoxy or ethoxy, B'' is hydrogen, chlorine, methoxy or ethoxy, C'' is hydrogen, methoxy or ethoxy and Alk is ethylene, n-propylene, alpha-methylethylene, or alpha-methyl-beta-hydroxyethylene.
Claim 9
Dependent Claim
19 words
The compound of claim 9 wherein A, B, C, and A'' are hydrogen and B'' and C'' are methoxy.
Claim 10
Dependent Claim
19 words
The compound of claim 9 wherein A and B are methoxy and C, A'', B'' and C'' are hydrogen.
Claim 11
Dependent Claim
20 words
The compound of claim 9 wherein A, B, C, A'', B'', and C'' are each hydrogen and R is methyl.
Claim 12
Dependent Claim
14 words
The compound of claim 9 wherein R is hydrogen and Alk is Alpha -methyl-ethylene.
Claim 13
Dependent Claim
16 words
The compound of claim 9 wherein R is hydrogen and Alk is Alpha -methyl- Beta -hydroxyethylene.
Claim 14
Dependent Claim
21 words
The compound of claim 9 wherein A and B are ethoxy, C is hydrogen and A'', B'' and C'' are methoxy.
Claim 15
Dependent Claim
21 words
The compound of claim 9 wherein A and B and A'' and B'' are methoxy and C and C'' are hydrogen.
Claim 16
Dependent Claim
22 words
The compound of claim 9 wherein A and B are ethoxy, A'' and B'' are methoxy and C and C'' are hydrogen.
Claim 17
Dependent Claim
18 words
The compound of claim 9 wherein A is chlorine and B, C, A'', B'' and C'' are hydrogen.
Claim 18
Dependent Claim
20 words
The compound of claim 9 wherein A and B are chlorine and C and A'', B'' and C'' are hydrogen.
Claim 19
Dependent Claim
22 words
The compound of claim 9 wherein A is methyl, A'' is trifluoromethyl and B and C and B'' and C'' are hydrogen.
Claim 20
Dependent Claim
18 words
The compound of claim 9 wherein A is trifluoromethyl and B, C, A'', B'' and C'' are hydrogen.
Claim 21
Dependent Claim
24 words
The compound of claim 9 wherein A, B and C are hydrogen, A'' and B'' are methoxy, C'' is hydrogen and R is methyl.
Claim 22
Dependent Claim
17 words
The compound of claim 9 wherein A, B and A'', B'' are methoxy and R is methyl.
Claim 23
Dependent Claim
12 words
The pharmaceutically acceptable acid addition salts of a compound of claim 9.
Claim 24
Dependent Claim
3 words
4-Cyano-4-phenyl- Beta -(3,4-dimethoxyphenyl)-ethyl-aminocyclohexane.
Claim 25
Dependent Claim
3 words
4-Cyano-4-phenyl- Beta -phenylethyl-aminocyclohexane.
Claim 26
Dependent Claim
3 words
4-Cyano-4-phenyl- Beta -(3,4,5-trimethoxyphenyl)-ethyl-aminocyclohexane.
Claim 27
Dependent Claim
3 words
4-Cyano-4- Beta -(3,4-diethoxyphenyl)-ethyl-aminocyclohexane.
Claim 28
Dependent Claim
3 words
4-Cyano-4-phenyl-N-methyl-N-( Beta -phenylethyl)-aminocyclohexane.
References Cited (Backward Citations)
US3261859A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-09-17 | 1977-03-19 | 1977-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-09-17 | 1981-03-19 | 1981-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-09-17 | 1985-03-19 | 1985-09-18 | $7700.00 | Window Closed / Lapsed |