Xanthone derivatives

Abstract

Abstract Xanthone derivatives of the formula: IN WHICH X represents a carboxyl or 5-(1H)-tetrazolyl group; and R1 and R2 which may be the same or different each represent a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms, a nitro group, a halogen atom or a group of the formula NR3R4 or OR3 or NR5SO2R6, (in which the groups R3 and R4 which may be the same or different each represent a hydrogen atom, a phenyl group, a benzyl group or an alkyl group which may optionally be substituted by an alkoxy group containing from 1 to 6 carbon atoms, a phenoxy group, phenyl group, an amino, alkylamino or dialkylamino group or by one or more hydroxy groups; and in which R5 is a hydrogen atom or an alkyl group containing from 1 to 6 carbon atoms and R6 is an alkyl group containing from 1 to 6 carbon atoms); with the proviso that when X represents a carboxyl group R1 and R2 do not both represent hydrogen atoms; and pharmaceutically acceptable non-toxic salts and esters of such compounds. These derivatives have pharmacological activity and in particular inhibit the release of spasmogen mediators from antigen-antibody reactions.

Inventors

• 👤 D Bays

Bibliographic Details