Erythromycin derivatives
Abstract
Abstract THE 2'',4"-DI-O-ALKANOYL AND THE 2'',4",11-TRI-O-ALKANOYL DERIVATIVES OR ERYTHROMYCIN ARE PREPARED BY ESTERFICATION OF ERYTHROMYCIN WITH AN APPROPRIATE ACID ANHYDRIDE. THESE RESULTING ESTER DERIVATIVES ARE INITIALLY DE-ESTERFIED IN THE 2''-POSITION TO PROPARE THE 4"-O-ALKANOYL OR THE 4",11-DI-O-ALKANOYL ERYTHORMYCIN, AND THEN, IF DESIRED, THESE DE-ESTERFICATION PRODUCTS ARE REACTED WITH ANOTHER ACID ANHYDRIDE TO PREPARE A DISSIMILARLY DI-SUBSTITUTED OR TRI-SUBSTITUTED ESTER. THROUGH REPETITIVE ESTERFICATION AND DE-ESTERFICATION, COMBINATIONS OF THE MONO SUBSTITUTED AND THE SIMILARLY OR DISSIMILARLY MULTIPLE SUBSTITUTED ERYTHROMYCIN ESTERS ARE PREPARED. THESE COMPOUNDS HAVE ANTIBIOTIC ACTIVITY.
Inventors
- 👤 P Jones
- 👤 T Perun
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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