Certain 4h-s-triazolo(4,3-a)(1,4)benzodiazepines

Abstract

Abstract THIS INVENTION RELATES TO NOVEL 4H-S-TRIAZOLO(J,3-A)(1,4)BENZODIAZEPINES EMBRACED BY THE FORMULA DIAZEPINE WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL OF 1 THROUGH 3 CARBON ATOMS, PHENYL, BENZYL, NITROMETHYL, CYANOMETHYL, LOWER ALKOXYMETHYL HAVING AN ALKOXY MOIETY OF 1 THROUGH 3 CARBON ATOMS, LOWER DIALKYLAMINOMETHYL HAVING AN ALKYL MOIETY OF 1 THROUGH 3 CARBON ATOMS, LOWER ALKYLTHIOMETHYL HAVING AN ALKYL MOIETY OF 1 THROUGH 3 CARBON ATOMS, PYRROLIDINOMETHYL, -COO-R'' WHEREIN R'' IS LOWER ALKYL OF 1 THROUGH 3 CARBON ATOMS, R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL OF 1 THROUGH 3 CARBON ATOMS, R2 IS SELECTED FROM THE GROUP CONSISTING OF PYRIDYL, 2-PYRIMIDYL, FURYL, PYRRYL, THIENYL, LOWER ALKYL OF 1 THROUGH 3 CARBON ATTOMS, LOWER ALKENYL OF 2 THROUGH 3 CARBON ATOMS, CYCLOALKYL OF 5 THROUGH 7 CARBON ATOMS AND CYCLOALKENYL OF 5 THROUGH 7 CARBON ATOMS, R3 AND R4 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL OF 1 THROUGH 3 CARBON ATOMS, HALOGEN, NITRO, TRIFLUOROMETHYL AND LOWER ALKOXY, LOWER ALKYLTHIO AND LOWER DIALKYLAMINO WHEREIN THEIR LOWER ALKYL MOIETIES ARE FROM 1 THROUGH 3 CARBON ATOMS, AND PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE NEW PRODUCTS OF FORMULA I ARE USEFUL AS SEDATIVES, HYNOTICS, TRANQUILIZERS, MUSCLE RELAXANTS AND ANTICONVULSANTS IN MAMMALS AND BIRDS. ALSO, AS FEED ADDITIVES FOR INCREASING GROWTH RATE ND FEED EFFICIENCY OF LIVESTOCK.

Inventors

• 👤 J Hester

Bibliographic Details