Patent US3733320A successfully refreshed from Google Patents.
US3733320A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibiotic purification processes
Assignee: Merck and Co Inc
•
Filing: 1971-03-03
•
Granted: 1973-05-15
•
Expires: 1991-03-03
Abstract
Abstract FERMENTATION BROTHS OR IMPURE SOLUTIONS CONTAINING 7B - (D-5-AMINO-5-CARBOXYVALERAMIDO)-3-(CARBAMOYLOXYMETHYL) - 7-METHOXY-3-CEPHEM-4-CARBOXYLIC ACID, A SUBSTANCE HAVNG ANTIBIOTIC ACTIVITY AGAINST GRAM-NEGATIVE AND GRAM-POSITIVE MICROORGANISMS, ARE PURIFIED USING (A) PASSAGE THROUGH A CATIONIC EXCHANGE RESIN, (B) ELUTION WITH A WEAK BASE, (C) PASSAGE THROUGH A WEAKLY BASIC ANIONIC EXCHANGE RESIN, (D) WASHING THE COLUMN RESIN OF STAGE C WITH A SOLUTION OF DULUTE LOWER ALKANOIB ACID, AND (E) ELUTION WITH A WEAK BASE OR A PHOSPHATE BUFFER SOLUTION. THEYIELD OF PRODUCT IS GREATLY INCREASED OVER PRIOR PURIFICATION PROCESSES.
Inventors
- 👤 S Pines
- 👤 N Jamieson
- 👤 M Kozlowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:47
CPC Classifications
C; C12; C12P; C12P35/00; C12P35/08
Claims Analysis
Total Claims: 0
No claims parsed yet. Click Sync Now above to re-index claims from Google Patents.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-05-14 | 1976-11-13 | 1977-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-05-14 | 1980-11-13 | 1981-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-05-14 | 1984-11-13 | 1985-05-15 | $7700.00 | Window Closed / Lapsed |