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US3726969A
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Accelerating the lysis of blood clots with urokinase and a benzylamine derivative
Assignee: Abbott Laboratories
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Filing: 1971-06-09
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Granted: 1973-04-10
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Expires: 1991-06-09
Abstract
Abstract Benzylamine and simple ring-substituted derivatives thereof have been found to potentiate blood clot lysis induced by urokinase when a combination of urokinase and these (substituted) benzylamines are brought in contact with clots of blood from vertebrate animals.
Inventors
- 👤 R Johnson
- 👤 J Short
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 12:41
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
19 words
The process of claim 1 wherein the blood clot is first contacted with said benzylamine and subsequently with urokinase.
Claim 2
Dependent Claim
120 words
A composition for accelerating the lysis of a vertebrate blood clot consisting essentially of urokinase and a non-toxic amount of a benzylamine of the formula wherein R is hydrogen, halogen, methyl, trifluoromethyl or methoxy and R'' is hydrogen, halogen, methyl, methoxy, hydroxy or trifluoromethyl or wherein R and R'' together form a second benzene ring fused to the phenyl ring at its 2- and 3-positions or a methylenedioxy ring attached to the phenyl ring at its 3-and 4-positions and R'''' is methoxy when R and R'' both are methoxy or hydroxy and hydrogen in all other instances; or a non-toxic acid addition salt thereof in which 0.1- 5 micromoles of said benzylamine per CTA unit of urokinase activity is present.
Claim 3
Dependent Claim
14 words
The composition of claim 3 wherein R is a chlorine substituent in the 2-position.
Claim 4
Dependent Claim
10 words
The composition of claim 4 wherein said benzylamine is 2-chloro-5-(trifluoromethyl)benzylamine.
Claim 5
Dependent Claim
10 words
The composition of claim 3 wherein said benzylamine is 2-fluorobenzylamine.
Claim 6
Dependent Claim
10 words
The composition of claim 3 wherein said benzylamine is 4-methoxybenzylamine.
Claim 7
Dependent Claim
28 words
The composition of claim 3 wherein the ratio between said benzylamine and urokinase is between 0.2 and 5.0 micromoles of said benzylamine per CTA unit of urokinase activity.
Claim 8
Dependent Claim
15 words
The composition of claim 8 in unit dosage form together with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
14 words
The composition of claim 9 wherein said carrier is a substantially isotonic saline solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-04-09 | 1976-10-09 | 1977-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-04-09 | 1980-10-09 | 1981-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-04-09 | 1984-10-09 | 1985-04-10 | $7700.00 | Window Closed / Lapsed |