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US3710117A Expired / Lapsed US ⏱️ 0.0 years remaining

Vitro test system for assessing thyroid function

Assignee: Yissum Research Development Co of Hebrew University of Jerusalem
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Filing: 1970-04-27
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Granted: 1973-01-09
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Expires: 1990-04-27
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Abstract

Abstract Improved in vitro test method and apparatus for assessing thyroid function comprising mixing a microquantity of blood serum with a predetermined amount of a radioactive isotope tagged thyroid hormone solution in the upper portion of a tubular body having a fixed geometry, said body containing a column of predetermined quantity of cross linked dextran gel as a secondary binding site in an aqueous fluid held between porous discs in the lower portion of the body and having valve means at the lower end thereof, allowing said mixture to enter said column, determining the total added thyroid hormone by a radioactivity measurement, washing or eluting said column with a suitable fluid, determining the amount of hormone retained in said column by a radioactivity measurement and making a calculation based on the ratio of the amount of retained hormone to the total amount of added hormone for the particular thyroid hormone being assessed.

Inventors

  • 👤 J Gross
  • 👤 A Gordon

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 03:38
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S436/00; Y10S436/804

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 19 words
Method as in claim 1 wherein the thyroid hormone is selected from the group consisting of thyroxine and triiodothyronine.
Claim 2
Dependent Claim 19 words
Method as in claim 1 wherein the quantity of serum used is about from 0.01 ml. to 0.15 ml.
Claim 3
Dependent Claim 32 words
Method as in claim 1 wherein the ratio of serum sample in ml. to dextran gel in mg. on a dry basis is in the range of about 1: 2000 to 1:60,000.
Claim 4
Dependent Claim 16 words
Method as in claim 4 wherein the ratio range is about from 1: 4500 to 1:9000.
Claim 5
Dependent Claim 15 words
Method as in claim 1 wherein the radioactivity measurements are made using a gamma counter.
Claim 6
Dependent Claim 12 words
Method as in claim 1 wherein the radioactive isotope is iodine 125.
Claim 7
Dependent Claim 15 words
Method as in claim 1 wherein the radioactivity measurements are made by counting the column.

References Cited (Backward Citations)

US3206602A Cited
US3376114A Cited
US3507618A Cited
US3451777A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1976-01-09 1976-07-10 1977-01-09 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1980-01-09 1980-07-10 1981-01-09 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1984-01-09 1984-07-10 1985-01-09 $7700.00 Window Closed / Lapsed

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