2-thiopyrimidine nucleosides
Abstract
Abstract 2-THIOPYRIMIDINE NUCLEOSIDES EXHIBITING CYTOTOXIC, ANTIVIRAL, ENZYME-INHIBITING AS WELL AS ANTIHYPERTHYROID EFFECTS ARE OBTAINED BY A NOVEL PROCESS COMPRISING REACTING A SILYL COMPOUND OF THE FORMULA A1-SI(-A2)(-A3)-S-C<(=N-Y=C(-R)-C(-X-SI(-A1)(-A2)-A3)=N-) WITH A MASKED HALOGEN SUGAR AND THEN SPLITTING OFF THE BLOCKING GROUPS, THE FINAL COMPOUNDS BEING OF THE FORMULA Z-N<(-C(=S)-NH-C(=X)(R-)-C=Y-) WHEREIN X IS O OR NH, Y IS N OR CH, R IS H, ALKYL OF 1-4 CARBON ATOMS, HALOGEN, NITRO, NITRILE LOWER ALKYLAMINO LOWER ALKOXY, OR THE GROUP -(CH2)N-CO-A WHEREIN N IS O, 1 OR 2 IS O-ALKYL OF 1-5 CARBON ATOMS NH2 OR LOWER ALKYLAMINO, AND Z IS A SUGAR RESIDUE, AND WHEREIN IN FORMULA I A1, A2 AND A3 REPRESENT LOWER ALKYL.
Inventors
- 👤 H Vorbruggen
- 👤 P Strehlke
Bibliographic Details
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