Certain 4-(4-pyridyl)-5-hydroxy-coumarin intermediates

Abstract

Abstract NOVEL CHEMICAL COMPOUNDS AND NON-TOXIC ACID ADDITION SALTS THEREOF ARE DISCLOSED WHEREIN THE COMPOUNDS HAVE THE FORMULAS: 2,2,3-TRI(R1-),4-(PYRID-4-YL),5-X,7-R2-CHROMAN (I) 2,2-DI(R1-),4-(PYRID-4-YL),5-X,7-R2-2H-CHROMENE (II) 2-(O=),4-(PYRID-4-YL),5-X,7-R2-2H-CHROMENE (III) IN WHICH R1 IS LOWER ALKYL HAVING 1 TO 6 CARBON ATOMS, R2 IS ALKYL HAVING 1 TO 20 CARBON ATOMS OR CYCLOALKYLLOWER-ALKYL, THE CYCLOALKYL PART HAVING 3 TO 8 CARBON ATOMS, AND X IS OH OR A PHARMACEUTICALLY ACCEPTABLE SALT INCLUDING AN ALKALI METAL SALT, OR AN ETHER OR ESTER OF THE OHGROUP, EXCLUSIVE OF AMINO ACID ESTERS. COMPOUNDS I AND II POSSESS BENEFICIAL PHARMACODYNAMIC ACTIVITY WITH RESPECT TO THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEM, AND COMPOUNDS III ARE INTERMEDIATES FOR USE IN THE PREPARATION OF COMPOUNDS I AND II.

Inventors

• 👤 Raj K Razdan
• 👤 William R Thompson

Bibliographic Details