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US3700768A
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Antibiotic am374 and method of production using streptomyces eburosporeus
Assignee: Wyeth Holdings LLC
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Filing: 1970-04-06
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Granted: 1972-10-24
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Expires: 1990-04-06
Abstract
Abstract A new antibiotic is produced, designated AM374, by fermenting under controlled conditions Streptomyces eburosporeus n.s. The new antibiotic is active against gram-positive bacteria and thus is useful in inhibiting the growth of such bacteria wherever they may be found. The invention also relates to a novel use of the new antibiotic as a growth promoter for animals.
Inventors
- 👤 Martin Paul Kunstmann
- 👤 John Norman Porter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:53
CPC Classifications
A; A23; A23K; A23K20/00; A23K20/10; A23K20/195; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
14 words
A compound as defined in claim 1, antibiotic AM374, in its essentially pure form.
Claim 2
Dependent Claim
17 words
A compound selected from the group consisting of antibiotic AM374, according to claim 1, and salts thereof.
Claim 3
Dependent Claim
129 words
Acid-hydrolysis product of antibiotic AM374 as defined in claim 1, which acid-hydrolysis product a. has the following elemental analysis: C, 52.54; H, 5.81; O, 25.52; N, 8.32; Cl, 7.11; b. has ultraviolet maxima at: 280 m Mu . cE1cm.1 46) in acidic solutions, 280 m Mu . cE1cm.1 51.5) in neutral solutions, 300 m Mu . (Ecm.1 86) in basic solutions, sh260 m Mu . cE1cm.1 143) in basic solutions; c. has an optical rotation: ( Alpha )D25 -69* ( + or - 3.6*) (C 0.839 in water); and d. exhibits characteristic infrared absorption at the following wavelengths expressed in microns: 3.0, 3.30sh, 3.43, 5.75sh, 5.92sh, 6.0, 6.15sh, 6.25, 6.48sh, 6.68, 6.85, 7.03, 7.18, 7.5, 7.67, 7.96sh, 8.30, 8.55sh, 8.86, 9.15, 9.45, 9.9, 10.45sh, 11.1, 11.55sh, 11.9, 13.3, 14.4.
Claim 4
Dependent Claim
37 words
A process which comprises cultivating Streptomyces eburosporeus NRRL 3582 in an aqueous nutrient medium under aerobic conditions until substantial antibacterial activity is imparted to said medium by the production of a compound as characterized in claim 1.
Claim 5
Dependent Claim
42 words
A process which comprises cultivating Streptomyces eburosporeus NRRL 3582 in an aqueous nutrient medium under aerobic conditions until substantial antibacterial activity is imparted to said medium by the production of a compound as characterized in claim 1 and isolating the compound therefrom.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-10-24 | 1976-04-24 | 1976-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-10-24 | 1980-04-24 | 1980-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-10-24 | 1984-04-24 | 1984-10-24 | $7700.00 | Window Closed / Lapsed |