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US3697502A
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Method of making iron dextran-preparations
Assignee: Individual
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Filing: 1969-11-03
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Granted: 1972-10-10
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Expires: 1989-11-03
Abstract
Abstract A substantially pure iron-dextran preparation is produced by a specific and simple process of reacting ferric chloride and dextran in aqueous solution in the presence of citric acid while maintaining the reaction temperature between about 50* C. and about 100* C. and the pH-value of the reaction mixture at a pH between about 9.0 and 10.0. The resulting iron-dextran preparation is substantially free of chloride ions. The novel process permits the preparation of iron-dextran preparations with a predetermined iron content.
Inventors
- 👤 Henry Marinus Christensen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:29
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
27 words
The process of claim 1, in which the precipitated iron-dextran preparation is further purified by dissolving it in pyrogen-free distilled water and reprecipitating the purified iron-dextran preparation.
Claim 2
Dependent Claim
22 words
The process of claim 1, in which precipitation of the iron-dextran preparation in step (d) is Effected by the addition of isopropanol.
Claim 3
Dependent Claim
19 words
The process of claim 2, in which reprecipitation of the iron-dextran preparation is effected by the addition of ethanol.
Claim 4
Dependent Claim
63 words
The process of claim 1 in which ethanol is used as the dextran precipitating solvent, the concentration of said solvent in step (a) is increased to about 89 percent, the concentration of said solvent in step (d) is increased to about 95 percent, and the concentration of said solvent in step (e) is reduced by the addition of water to about 89 percent.
Claim 5
Dependent Claim
21 words
The process of claim 1, in which the temperature during reaction is kept between about 80* C. and about 90* C.
Claim 6
Dependent Claim
23 words
The process of claim 1, in which the dextran reacted with ferric chloride has a molecular weight between about 3,000 and about 20,000.
Claim 7
Dependent Claim
17 words
The process of claim 1, in which the dextran reacted with ferric chloride is dextran glycerol glycoside.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-10-10 | 1976-04-10 | 1976-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-10-10 | 1980-04-10 | 1980-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-10-10 | 1984-04-10 | 1984-10-10 | $7700.00 | Window Closed / Lapsed |