Abstract Compounds of the formula h WHEREIN Z and Z'' are hydroxy and Y and Y'' are H, -COCH3, or COOR'' (R'' being an alkyl group) are used to prepare compounds of the formula AND THERAPEUTICALLY ACCEPTABLE SALTS, ESTERS AND AMIDES THEREOF, WHEREIN R1, R2, R3, R4, R5 and R6 are the same or different and each is H or halogen, lower alkyl, hydroxy, lower alkoxy, substituted lower alkyl or substituted lower alkoxy, and X is a saturated or unsaturated, substituted or unsubstituted, straight or branched polymethylene chain which may be interrupted by one or more carbocyclic rings or oxygen-containing heterocyclic rings, oxygen atoms or carbonyl groups. The latter compounds are useful as inhibitors of certain antigen-antibody reactions, being particularly useful for the relief and prophylaxis of asthma.
A compound of the formula in which R1, R2, R3, R4, R5 and R6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxylower alkyl, haloloweralkyl, hydroxyloweralkoxy, and loweralkoxyloweralkoxy, and X represents a saturated hydrocarbon chain which is unsubstituted or which is substituted by a member of the group consisting of halogen, hydroxy or lower alkoxy with the proviso that when R1, R2, R3, R4, R5 and R6 are hydrogen, X is not a group -CH2-CHOH-CH2-linking the two positions para to the acetyl groups.
Claim 2
Dependent Claim
11 words
A compound according to claim 2 wherein X represents the group
Claim 3
Dependent Claim
10 words
A compound according to claim 3, said compound being 1,3-bis(2-acetyl-3-hydroxyphenoxy)-2-hydroxypropane.