Method of enhancing the action of a medicament

Abstract

Abstract This invention is concerned with a method of prolonging the action of a medicament in a mammal by administering parenterally thereto an emulsion comprising an aqueous phase dispersed substantially uniformly throughout a metabolizable vegetable, animal or hydrocarbon oil containing one or more hydrocarbons of about 12 to 18 carbon atoms, the aqueous phase having an average particle size of about 0.1 to 10 microns and including an effective dose of a medicament. The medicament may be therapeutic or prophylactic in nature, and more specifically, may include live or killed microorganisms, pollen extract and a host of other materials. In another aspect of the invention non-specific resistance of the mammal is induced by administering parenterally the aforedescribed emulsion in which the medicament is a lipopolysaccharide and such an emulsion induces in the mammal resistance to radiation, shock and infection when subjected thereto. In a specific sense the fetus of a mammal may derive higher resistance to infection or radiation by administration to the female mammal the aforedescribed emulsion. The oil phase of the emulsion decreases the LD50 of a toxic medicament. The mammals in which such responses can be achieved are mice, rabbits, monkeys, rats, guinea pigs, pigs, dogs, and the like.

Inventors

• 👤 Samuel J Prigal

Bibliographic Details