Biodegradable parenteral microspherules

Abstract

Abstract TINY SUBSTANTIALLY SPHERULAR PARTICLES HAVING A SMOOTH OUTER SURFACE AND ESSENTIALLY VOID-FREE INTERIOR, ARE PRODUCED CONSISTING ESSENTIALLY OF SOLID, COLD-WATER, INSOLUBLE MATERIAL COMPRISING A PHYSIOLOGICALLY ACCEPTABLE, PARENTERALLY METABOLIZABLE PROTEIN, SAID SPHERULES BEING CAPABLE OF BEING MADE RADIOACTIVE AFTER THEIR PREPARATION, AND SAID RADIOACTIVITY BEING SUBSTANTIALLY NON-LEACHABLE UPON SHORT TERM EXPOSURE TO COLD WATER. THEY CAN BE USED AS CARRIERS FOR SUBSTANCES, E.G. RADIOISOTOPES, WHICH ARE ADMINISTERED PARENTIALLY FOR DIAGNOSTIC, PROPHYLATIC OR THERAPEUTIC PURPOSES. ON ADMINISTRATION IN THIS WAY, THEY PROVIDE A PREDETERMINABLE DWELL TIME AND THEREAFTER ARE BROKEN DOWN OR SOLUBILIZED BY THE BODY FLUIDS OVER A PREDETERMINABLE PERIOD RANGING FROM MINUTES TO SEVERAL DAYS. THEREAFTER THE RADIOISOTOPIC OR OTHER MATERIAL IS EXCRETED FROM THE BODY THUS TERMINATING EXPOSURE TO THE CARRIED SUBSTANCE.

Inventors

• 👤 Roger L Evans

Bibliographic Details