N-substituted and n,n - disubstituted aminocarbonylalkyl compounds and their production

Abstract

Abstract N-SUBSTITUTED AND N, N-DISUBSTITUTED AMINOCARBONYLALKYL COMPOUNDS OF THE FORMULA: R2-N(-R3)-OC-A-N<(-(R1-1,2-PHENYLENE)-Z-CO-) WHEREIN Z IS SULFUR OR LOWER ALKYLAMINO, A IS LOWER ALKYLENE, R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR TRIFLUOROMETHYL R2 IS HYDROGEN, LOWER ALKYL OR HYDROXY (LOWER)ALKYL AND R3 IS HYDROGEN, LOWER ALKYL, HALO(LOWER) ALKYL, HYDRONY(LOWER)ALKYL, LOWER ALKOXY(LOWER)ALKYL, HYDROXY(LOWER)ALKOXY(LOWER)ALKYL, HYDROXYCARBONYL(LOWER)ALKYL, LOWER ALKOXYCARBONY(LOWER)ALKYL, PHENY BEARING OR NOT ONE OR MORE OF LOWER ALKYL, HALOGEN, HYDROXYL, LOWER ALKOXY AND LOWER ALKANOYL, PHENYL(LOWER)ALKYL HAVING OR NOT ON THE BENZENE RING ONE OR MORE OF LOWER ALKYL, HALOGEN, HYDROXYL, LOWER ALKOXY AND LOWER ALKANOLY, OR THE GROUP OF THE FORMULA: -A''-N(-R4)-R5 IN WHICH A'' IS LOWER ALKYLENE AND R4 AND R5 ARE EACH LOWER ALKYL OR PHENYL OR, WHEN TAKEN TOGETHER WITH THE ADJACENT NITROGEN ATOM, REPRESENTS A 5 TO 7-MEMBERED NITROGEN CONTAINING HETEROCYCLIC GROUP, OR THE GROUP OF THE FORMULA: -N(-R2)-R3 MAY REPRESENT A 3 TO 7-MEMBERED HETROCYCLIC GROUP, PROVIDED THAT R1 IS NOT HYDROGEN WHEN R2 AND R3 ARE EACH LOWER ALKYL OR, IN THE LINKED FORM, REPRESENT A LOWER ALKYLENE GROUP OR AN OXA(LOWER)ALKYLENE GROUP AND R1 IS NOT CHLORINE WHEN BOTH R2 AND R3 ARE HYDROGEN. THESE COMPOUNDS EXHIBIT PHARMACOLOGICAL ACTIVITY SUCH AS ANTINFLAMMATORY ACTIVITY OR ANTIARRHYTHMIC ACTIVITY.

Inventors

• 👤 Suminori Umio

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