N-trityl-imidazoles for treating fungal infections
Abstract
Abstract WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANTIMYCOTICS. 1-(((X)A-PHENYL)-C(-PHENYLENE-(X")A")-),(X'')A''-BENZENE WITH A TRITYL HALIDE OF THE FORMULS: 2-R,4-R1,5-R2-IMIDAZOLE WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X, X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA: ,2-R,4-R1,5-R2-IMIDAZOLE 1-(((X)A-PHENYL)-C(-PHENYLENE-(X")A")(-PHENYLENE-(X'')A'')-) N-TRITYL-IMIDAZOLES AND SALTS THEREOF OF THE FORMULA:
Inventors
- 👤 Karl H Buchel
- 👤 Manfred Plempel
Bibliographic Details
Claims Analysis
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