Meningococcal polysaccharide vaccines
Abstract
Abstract THIS DISCLOSURE DESCRIBES A PROCESS FOR PREPARING AND ISOLATING ANTIGENIC GROUP-SPECIFIC POLYSACCHARIDES OF SEROLOGIC GROUP A AND GROUP C MENINGOCOCCI USED AD VACCINES. THE PROCESS EMPLOYS A CATIONIC SUBSTANCE, SUCH AS HEXADECYL TRIMETHYLAMMONIUM BROMIDE, TO PRECIPITATE THE POLYSACCHARIDE FROM THE WHOLE CULTURE. THE ANTIGENIC PLOYSACCHARIDES ISOLATED BY THIS PROCESS ARE OF HIGH MOLECULAR WEIGHT (MOLECULAR WEIGHT 60,000-5,000,000). THE MAIN CONSTITUENT OF THE ANTIGENIC GROUP A POLYSACCHARIDE IS N-ACTYL, O-ACTEYL MANNOSAMINE PHOSPHATE AND THE MAIN CONSTITUENT OF THE ANTIGENIC GROUP C POLYSACCHARIDE IS N-ACETYL, O-ACETYL NEURAMINIC ACID. THE TWO ANTIGENIC POLYSACCHARIDES ARE USEFUL FOR PRODUCNG IMMUNITY AGAINST MENIGOCOCCAL MENINGITIS IN HUMANS.
Inventors
- 👤 Emil C Gotschlich
Bibliographic Details
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