Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
Abstract
Abstract 3 - AMINO - 2 - SUBSTITUTED - 4,4,4 - TRIFLUORO - 2 - BUTENENITRILES ARE REACTED WITH ISCYANATES OR ISOTHIOCYANATES IN THE PRESENCE OF AN INERT SOLVENT AND FROM 0.75 TO ABOUT 1.0 MOLE EQUIVALENTS OF STRONG BASE PER MOLE OF BUTENENITRILE TO PRODUCE THE NOVEL UREIDO BUTENEITRILES OF THE FORMULA: NC-C(-HALO)=C (-CF3)-NH-C(=X)-NH-R PYRIMIDINE WHEREIN R IS ALKYL, ALKENYL, PHENYL, BENZYL AND SUBSITUTED DERIVATIVES THEREOF AND X IS SULFUR OR OXYGEN. THE UREIDO BUTENENITRILES ARE TREATED WITH ADDITIONAL BASE TO PRODUCE NOVEL CYCLIC CYTOSINES OF THE FORMULA; 2(=X),3-R,4-(=NH),5-(HALO-),6-(F3C-)-1,2,3,4-TETRAHYDRO WHEREIN R AND X ARE AS DEFINED ABOVE. THE CYTOSINES CAN BE PRODUCED DIRECTLY BY TREATING 3-AMINO-2-SUBSITUTED4,4,4-TRIFLUORO-2-BUTENENTRILE WITH AT LEAST 1.0 MOLE EQUIVLAENTS OF BASE. THE NOVEL COMPOUNDS ARE USEFUL INTERMEDIATES IN THE PREPARATION OF HERBICIDAL URACILS AND THIOURACILS.
Inventors
- 👤 Albert William Lutz
Bibliographic Details
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