AMINO-LOWER-ALKOXY-DIBENZO{8 a,d{9 CYCLOHEPTENES AND 5-ALKYL and -ARALKYL DERIVATIVES

Abstract

Abstract Dibenzo(a,d)cyclohepten-5-ones and 10,11-dihydro derivatives thereof substituted on one of the benzene rings by an aminolower-alkoxy group are prepared by reacting the corresponding hydroxydibenzo(a,d)cyclohepten-5-ones with an amino-lower-alkyl halide. The 5-carbonyl group is subsequently converted by reduction, Grignard and dehydration reactions to the groups CH2, CH(OH), C(lower-alkyl)(OH), C(phenyl-lower-alkyl)(OH), C (loweralkylidene), C (phenyl-lower-alkylidene), CH(lower-alkyl) or CH(phenyl-lower-alkyl). The compounds are useful as antidepressant agents.

Inventors

• 👤 John W Schulenberg
• 👤 Sydney Archer

Bibliographic Details