1-alkyl-1,2,5,6-tetrahydro-3-pyridylmethyl carboxylic

Abstract

Abstract 1-ALKYL-1,2,5,6-TETRAHYDRO-3-PYRIDYLMETHYL CARBOXYLIC ACID ESTERS OF THE FORMULA WHEREIN R is selected from the group consisting of alkyl of two to 10 carbon atoms optionally substituted with cyano or alkoxy of one to seven carbon atoms, branched alkyl of three to five carbon atoms, alkenyl of two to three carbon atoms optionally substituted with a halogen, alkynyl of two to three carbon atoms, cycloalkyl of three to six carbon atoms and phenyl alkyl of one to seven alkyl carbon atoms, R1 is selected from the group consisting of hydrogen, methyl, -OH and C1-, R2 is selected from the group consisting of hydrogen, phenyl, cycloalkyl of five to six carbon rings and R1 and R2 together with the carbon to which they are attached form a five to six member cycloaliphatic ring, R3 is phenyl and when R2 and R3 are each phenyl they may optionally be linked together in the orthopositions by a direct bond or through an oxygen atom and their nontoxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts which compounds possess spasmolytic and central sedative properties without undesirable side effects usually associated with spasmolytics.

Inventors

• 👤 Hans-Hugo Hubner
• 👤 Gerhard Walther
• 👤 Karl Zeile
• 👤 Helmut Wick
• 👤 Klaus Stockhaus

Bibliographic Details