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US3607646A
Expired / Lapsed
US
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Method for the preservation of animal or human organs in living condition
Assignee: Air Liquide SA
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Filing: 1969-04-02
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Granted: 1971-09-21
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Expires: 1989-04-02
Abstract
Abstract A method and apparatus is described, pertaining to the preservation of living tissue such as an organ excised from the body for an extended time in view of future transplant thereof. The organ is placed in a refrigerated environment and under pressure while a nutrient fluid is circulated through its arterial complex. The gas utilized for pressurizing the environment of the organ is biochemically inert and serves as a carrier of oxygen which is absorbed by the nutrient, the latter being subjected to the influence of the pressurizing gas.
Inventors
- 👤 Henry De Roissart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 13:49
CPC Classifications
A; A01; A01N; A01N1/00; B; B65; B65D; B65D39/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
34 words
The method in accordance with claim 1, wherein the quantity of oxygen dispersed in the nutrient circulating fluid is in the order of 1/10 to 2/10 milliliter of oxygen for 100 milliliters of fluid.
Claim 2
Dependent Claim
28 words
The method in accordance with claim 1, wherein the pressure of the gas dispersed in said fluid is below that of the pressurized environment of the living organ.
Claim 3
Dependent Claim
14 words
The method in accordance with claim 1, wherein said biochemically inert gas is Helium.
Claim 4
Dependent Claim
38 words
The method in accordance with claim 1, wherein the organ is maintained at said elevated pressure by applying thereto a neutral biochemical gas having a high permeation and an oxygen content below that of 10 percent by volume.
Claim 5
Dependent Claim
28 words
The method in accordance with claim 5, wherein the gas utilized for maintaining the organ under pressure is the same as the gas dispersed in the circulating fluid.
Claim 6
Dependent Claim
34 words
The method in accordance with claim 5, wherein the gas which contains the oxygen supply for the circulating fluid is biochemically inert and has an oxygen content of about 1 percent to 5 percent.
Claim 7
Dependent Claim
84 words
In a method of keeping alive an organ of human or animal origin by maintaining said organ under refrigeration and in an environment of elevated pressure, while infusing and circulating in said organ a nourishing fluid containing oxygen, the improvement which comprises; effecting differential decompression, first by reducing the pressure of a gas carrying oxygen to the fluid to the point of bringing it back to atmospheric pressure, followed, after complete purging of the organ, by a reduction in the pressure of the environment.
Claim 8
Dependent Claim
94 words
In a method for preserving an organ, the steps of sealing the organ in an enclosed vessel, pressurizing said vessel, mixing oxygen and an inert gas in a container therefor to provide a gaseous mixture having an oxygen content not greater than about 10 percent by volume, dispersing the gaseous mixture in a nutrient fluid, maintaining said nutrient fluid under a pressure less than the pressure within said vessel during the dispersal of the gaseous mixture in said fluid, and transmitting the nutrient fluid containing the dissolved mixture to the organ within said vessel.
Claim 9
Dependent Claim
109 words
In a method for preserving an organ, the steps of sealing the organ in an enclosed vessel, maintaining the temperature within said vessel below about 37* C., pressurizing said vessel, mixing oxygen and a biochemically inert gas in a container therefor to provide a gaseous mixture having a high permeation and an oxygeN content not greater than about 10 percent by volume, dispersing the gaseous mixture in a nutrient fluid, maintaining said nutrient fluid under a pressure less than the pressure within said vessel during the dispersal of the gaseous mixture in said fluid, and transmitting the nutrient fluid containing the dissolved mixture to the organ within said vessel.
Claim 10
Dependent Claim
16 words
In a method in accordance with claim 10, the vessel being pressurized with said gaseous mixture.
Claim 11
Dependent Claim
150 words
In a method for preserving an organ, the steps of sealing the organ in an enclosed vessel, maintaining the temperature within said vessel below about 37* C., mixing oxygen and helium in a container therefor to provide a gaseous mixture having a high permeation and an oxygen content between about 1.0 percent and about 5.0 percent by volume, feeding the gaseous mixture directly from its container to said enclosed vessel to pressurize said vessel, also feeding the gaseous mixture from its container to a second container having a nutrient fluid therein, dispersing the gaseous mixture in said nutrient fluid, regulating the pressure of said gaseous mixture to maintain said nutrient fluid under a pressure less than the pressure within said vessel during the dispersal of the gaseous mixture in said fluid, and transmitting the nutrient fluid containing the dissolved mixture from said second container to the organ within said vessel.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-09-20 | 1975-03-22 | 1975-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-09-20 | 1979-03-22 | 1979-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-09-20 | 1983-03-22 | 1983-09-21 | $7700.00 | Window Closed / Lapsed |