Method of diagnosing cystic fibrosis
Abstract
Abstract A METHOD FOR ELECTRICALLY DIAGNOSING CYSTIC FIBROSIS BY WETTING THE CLEANSED SKIN OF A PATIENT WITH A SOLUTION CONTAINING CHLORIDE IONS IN A CONCENTRATION OF ABOUT FORTY (40) MILLIEQUIVALENTS PER LITER AND THEN DETERMINING THE DIRECTION OF A SIGNAL DEVELOPED BY CHLORIDE RESPONSE ELECTRODE IN CONTACT WITH THE PATIENT''S SKIN. THIS TECHNIQUE IS ADVANTAGEOUSLY CARRIED OUT WITH AN ELECTROCHEMICAL ELECTRODE STRUCTURE HAVING AN ELONGATED BODY WITH AN AXIAL CHAMBER AND AN ANNULAR CHAMBER, BOTH SEPARATED FROM ONE ANOTHER. BOTH CHAMBERS CONTAIN A REFERENCE ELECTRODE AND A REFERENCE ELECTROLYTE. ONE END OF THE STRUCTURE INCLUDES AN INSET, FLAT, MEMBRANE SENSI- TIVE TO SPECIFIC IONS OF ONE POLARITY FORMING A WALL FOR THE AXIAL CHAMBER. IN ONE FORM OF THE ELECTRODE, AN ANNULAR LEAK, COMMUNICATING WITH THE ANNULAR CHAMBER, SURROUNDS AND IS SPACED FROM THE MEMBRANE SURFACE, THAT END OF THE STRUCTURE THEREFORE PROVIDING A SUBSTANTIALLY FLAT, RIDGELESS SURFACE. IN ANOTHER FORM, A RING-SHAPED MEMBRANE, SENSITIVE TO IONS OF OPPOSITE PLARITY, SURROUNDS AND IS SPACED FROM THE CENTRAL MEMBRANE, AND NO LEAK IS USED.
Inventors
- 👤 John H Riseman
- 👤 Stanley Shiller
Bibliographic Details
Claims Analysis
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