N-4-phenyl-1-piperazinylalkyl-5-phenyl-oxazolidinones
Abstract
Abstract N - 4 - PHENYL - 1 - PIPERAZINYLALKYL-5-PHENYL-OXAZOLIDIONES OF THE STRUCTURAL FORMULA: 3-(PHENYL-(1,4-PIPERAZINYLENE)-(CH2)N-),4-R,4-R1, 5-(PHENYL)-OXAZOLIDIN-2-ONE IN WHICH R IS H OR METHYL, R1 IS H OR METHYL, OR RR1 IS OXYGEN; AND N IS AN INTEGER FROM 2 TO 5; AND PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF. THESE COMPOUNDS ARE USEFUL AS ANTIHYPERTENSIVE AGENTS. THESE COMPOUNDS ARE PREPARED BY: (A) CONDENSATION OF A STYRENE OXIDE WITH 4-ARYL-1-PIPERAZINYLALKYLAMINE TO FORM AN INTERMEDIATE AMINOALCOHOL, OR (B) REACTING A B-HYDROXYPHENETHYLAMINE WITH A 4-ARYL-1-PIPERAZINYLALKYL HALIDE TO FORM THE INTERMEDIATE AMINOALCOHOL, OR (C) REACTING AN ALKYL MANDELATE WITH 4-ARYL-1-(W-AMINOALKYL)PIPERAZINE TO FROM AN INTERMEDIATE MANDELAMIDE; AND TREATING THE MANDELAMIDE WITH PHOSGENE OR ETHYL CHLOROFORMATE TO EFFECT RING CLOSURE.
Inventors
- 👤 Robert Norman Schut
Bibliographic Details
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