Patent DE539468C successfully refreshed from Google Patents.
Patent US3563958A successfully refreshed from Google Patents.
US3563958A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Esterification of arylmethylene sulfonium resins with n - protected amino acids for use in solid-phase peptide synthesis
Assignee: Dow Chemical Co
•
Filing: 1968-04-02
•
Granted: 1971-02-16
•
Expires: 1988-04-02
Abstract
Abstract THE MERRIFIELD SOLID-PHASE PEPTIDE SYNTHESIS IS IMPROVED BY BONDING THE AMINO ACID TO THE SUPPORTING RESIN THROUGH REACTION OF AN N-PROTECTED AMINO ACID (I) WITH AN ARYLMETHYLENE SULFONIUM RSIN (II) TO FORM AN AMINO ACID RESIN BENZYL ESTER (IV): P-NH-CH(-R)-COOH + X-AR-CH2-S(+)(-R1)-R2.Y(-) --> P-NH-CH(-R)-COO-CH2-AR-X ADVANTAGES OF THIS PROCESS INCLUDE BROADER SCOPE, MILD CONDITIONS, HIGHER RESIN ESTER CAPACITIES AND IMPROVED YIELDS. HIGHEST YIELDS ARE OBTAINED WHEN A BASIC SALT OF THE SULFONIUM RESIN IS USED.
Inventors
- 👤 Linneaus C Dorman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:56
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/04; C07K1/042
Claims Analysis
Total Claims: 0
No claims parsed yet. Click Sync Now above to re-index claims from Google Patents.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-02-15 | 1974-08-17 | 1975-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-02-15 | 1978-08-17 | 1979-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-02-15 | 1982-08-17 | 1983-02-16 | $7700.00 | Window Closed / Lapsed |