Azecino(2,1-a)tetrahydroisoquinolines and process for their production
Abstract
Abstract THE PRESENT INVENTION RELATES TO COMPOUNDS OF THE FORMULA: 1,2-(-CH(-R3)-A-CH(-R4)-CH2-(CH2)N-CH2-C(=B)-),6-R1,7-R2- 1,2,3,4-TETRAHYDROISOQUINOLINE, 1,2-(=C(-R3)-R5-CH(-R4)-CH2-(CH2)N-CH2-C(=B)-),2-R6,6-R1, 7-R2-1,2,3,4-TETRAHYDROISOQUINOLINE, (2-R6,6-R1,7-R2-1,2,3,4-TETRAHYDROISOQUINOL-1-YL)-CH(-R3)- CH<(-CH(-R4)-CH2-(CH2)N-CH2-COO-) AND 6-R1,7-R2-1,2,3,4-TETRAHYDROISOQUINOLINE WHEREIN B IS OXYGEN OR HYDROGEN; A IS >CHOH, >CHOSO2C6H4CH3, >C=O, >CH2, >C=NOH, >C=NOCOCH3, >CONH; R1 AND R2 ARE HYDROGEN, LOWER ALKOXY, HYDROXY, OR IF TAKEN TOGETHER, METHYLENEDIOXY; R3 IS HYDROGEN, HALOGEN, LOWER ALKYL, ARALKYL, LOWER ALKOXY; R4 IS ALKYL, ARALKYL, ARYL, CARBOALKOXY, HALOGEN; N IS 1-20; R5 IS >C=O OR >C=NOH; R6 IS HYDROGEN, ACYL OR TOSYL; R7 IS HYDROXY, LOWER ALKOXY, AMINE, LOWER ALKYLAMINE AND ARALKYLAMINE. THESE COMPOUNDS ARE USEFUL AS ANTIHYPERTENSION AGENTS.
Inventors
- 👤 John Shavel Jr
- 👤 Chester Puchalski
- 👤 Marx Von Strandtmann
Bibliographic Details
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