Plasminogen activator and isolation thereof from stromata of human erythrocytes
Abstract
Abstract A NEW PLASMINOGEN ACTIVATOR DISTINGUISHABLE FROM UROKINASE CAN BE ISOLATED FROM STROMATA OF HUMAN ERYTHROCYTES AT A PH OF FROM ABOUT 1 TO 4. THE PLASMINOGEN ACTIVATOR IS USEFUL FOR THE THERAPY AND PROPHYLAXIS OF THROMBOSES AND EMBOLISMS. THE PLASMINOGEN ACTIVATOR IS ADMINISTERED IN THE FORM OF AN INJECTABLE SOLUTION WHICH CAN BE PREPARED BY TECHNIQUES WHICH ARE PER SE KNOWN IN A THERAPEUTIC DOSAGEOF TE SAME ORDER OF MAGNITUDE AS UROINASE. IT HAS A MOLECULAR WEIGHT AFTER PROCESSING IN THE ULTRACENTRIFUGE BETWEEN ABOUT 20,000 AND 50,000. IT IS A PROTEIN, ACID STABLE TO PH 1 BUT IS ALMOST ENTIRELY DESTROYED AT PH 9-10 AT +4*C. FOR 5 HOURS. IT IS ACTIVATED OR CATALYZED BY SMALL AMOUNTS OF UROKINASE WHICH RAISED ITS ACTIVITY 20-100 FOLD.
Inventors
- 👤 Otto Wagner
Bibliographic Details
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