1-(2-benzoylcyclopropylmethyl)-4-phenyl-1,2,5,6- tetrahydropyridines
Abstract
Abstract 1 - (2- BENZOYLCYCLOPROPYLMETHYL) - 4 - PHENYL-1,2,5,6TETRAHYDROPYRIDINES AND RELATED 4-PHENYLPIPERAZINES IN WHICH THE BENZOYL GROUP AND/OR THE PHENYL MOIETY MAY BE SUBSTITUTED BY CHLORO, BROMO, FLUORO, TRIFLUOROMETHYL, METHYL OR METHOXY, AS WELL AS THE ETHYLENE KETALS THEREOF, HAVE TRANQUILIZING ACTIVITY. THE COMPOUNDS ARE GENERALLY PREPARED FROM A 2-BENZOYLCYCLOPROPANECARBOXYLIC ACID VIA REACTION OF THE TRIETHYLAMINE SALT WITH ETHYL CHLOROFORMATE TO GIVE THE MIXED ANHYDRIDE WHICH IS CONDENSED WITH A 4-PHENYL-4-PEPERIDONOL OR 1-PHENYLPIPERAZINE TO GIVE A CORRESPONDING AMIDE. THE ETHYLENE KETAL OF THE AMIDE IS REDUCED TO THE CYCOPROPYLMETHYL DERIVATIVE WHICH IS HYDROLYZED WITH ACID TO FREE KETONE PRODUCT.
Inventors
- 👤 Carl Kaiser
- 👤 Charles L Zirkle
Bibliographic Details
Claims Analysis
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| 3.5 Years (Year 4) | 1974-01-04 | 1974-07-06 | 1975-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-01-04 | 1978-07-06 | 1979-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-01-04 | 1982-07-06 | 1983-01-05 | $7700.00 | Window Closed / Lapsed |