3-methyl-8-(2-thinenyl)pyrazolo(4,3-e)(1,4) diazepin-5(1h)-one compounds
Abstract
Abstract 3 - METHYL-8-(2-THIENYL)PYRAZOLO(4,3-E)(1,4)DIAZEPIN5(4H)-ONE COMPOUNDS, 7-OXIDE DERIVATIVES THEREOF, AND THEIR SALTS, SUBSTITUTED IN THE 1-POSITION BY METHYL OR ETHYL AND OPTIONALLY IN THE 4-POSITION BY METHYL; AND THEIR PRODUCTION BY (A) REACTING A 4-AMINO-3-METHYL-5(2-THENOYL)PYRAZOLE WITH A LOWER ALKYL ESTER OF GLYCINE OR A SALT THEREOF, (B) REACTING A 4-(2-HALOACETAMIDO)-3METHYL-5-(2-THENOYL)PYRAZOLE OR A SALT THEREOF WITH AMMONIA, (C) REACTING A 4-(2-AMINOACETAMIDO)-3-METHYL5-(2-THENOYL)PYRAZOLE SALT WITH A BASE, (D) REACTING A 4-(2-(HYDROXYLAMINO)ACETAMIDO) - 3 - METHYL-5-(2-THENOYL)PYRAZOLE WITH A STRONG ACID, (E) REACTING ONE OF THE 3-METHYL - 8 - (2-THIENYL)PYRAZOLO(4,3-E)(1,4)DIAZEPIN-5 (1H)-ONE COMPOUNDS WITH AN OXIDIZING AGENT, AND (F) REACTING ONE OF THE 4-UNSUBSTITUTED 3-METHYL-8-(2-THIENYL)PYRAZOLO(4,3-E)(1,4)DIAZEPIN-5(1H) ONES OR THE 7-OXIDE DERIVATIVES THEREOF WITH A METHYLATING AGENT IN THE PRESENCE OF A BASE. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANTICONVULSANT AND ANTI-ANXIETY AGENTS.
Inventors
- 👤 Yvon J L Italien
- 👤 Ivan C Nordin
Bibliographic Details
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