Stable syringeable suspensions of parenteral drugs in complex floc form

Claim 1

A METHOD OF PRODUCING A STABLE SYRNGEABLE HYPODERMICALLY INJECTABLE SUSPENSION OF A DRUG COMPLEX COMPRISING IN COMBINATION, REACTING AQUEOUS SOLUTIONS OF AT LEAST ONE NONIONIC SURFACTANT OF A POLYETHER TYPE AND AN AQUEOUS SOLUTION OF AT LEAST ONE HYDROXYLATED, PHYSIOLOGICALLY PARENTERALLY ACCEPTABLE PRESERVATIVE HAVING AN ACTIVE HYDROGEN CAPABLE OF HYDROGEN BONDING WITH THE OXYGEN OF THE ETHER LINKAGES IN THE NONIONIC SURFACTANT, SAID PRESERVATIVE BEING SELECTED FROM THE GROUP CONSISTING OF PHENOL, BENZYL ALCOHOL, ALKYL ESTERS OF PARAHYDROXY BENZOIC ACID, CHLOROBUTANOL, BETANAPTHOL AND RESORCINOL ADJUSTING THE CONCENTRATIONS AND TEMPERATURE TO PRODUCE A VISUALLY TURBID DISPERSION, THE HYDROXYLATED PARENTERALLY ACCEPTABALE PRESERVATIVE BEING IN HIGHER CONCENTRATION THAN NORMALLY REQUIRED FOR PRESERVATIVE ACTION BUT WITHIN PARENTERALLY ACCEPTABLE CONCENTRATIONS, COMPLEXING FINELY DIVIDED SOLID PARENTERALLY USEFUL DRUG WITH THE TURBID DISPERSION TO FOR A SUSPENSION OF STABLE FLOCS OF THE COMPLEXED DRUG AND REACTION PRODUCT OF THE NONIONIC SURFACE ACTIVE AGENT AND PARENTERALLY ACCEPTABLE PRESERVATIVE, SAID SUSPENSION BEING ADAPTED FOR HYPODERMIC INJECTION THROUGH THE HYPERDERMIC NEEDLE OF THE SYRINGE AFTER BEING BROUGHT UP TO FINAL DESIRED VOLUME BY WATER FOR INJECTION, AND BEING WITHOUT SERIOUS STICKING OF THE FLOCS TO THE BARREL OF THE SYRINGE NEEDLE.

Claim 2

A METHOD OF PRODUCING A STABLE SYRNGEABLE HYPODERMICALLY INJECTABLE SUSPENSION OF A DRUG COMPLEX COMPRISING IN COMBINATION, REACTING AQUEOUS SOLUTIONS OF AT LEAST ONE NONIONIC SURFACTANT OF A POLYETHER TYPE AND AN AQUEOUS SOLUTION OF AT LEAST ONE HYDROXYLATED, PHYSIOLOGICALLY PARENTERALLY ACCEPTABLE PRESERVATIVE HAVING AN ACTIVE HYDROGEN CAPABLE OF HYDROGEN BONDING WITH THE OXYGEN OF THE ETHER LINKAGES IN THE NONIONIC SURFACTANT, SAID PRESERVATIVE BEING SELECTED FROM THE GROUP CONSISTING OF PHENOL, BENZYL ALCOHOL, ALKYL ESTERS OF PARAHYDROXY BENZOIC ACID, CHLOROBUTANOL, BETANAPTHOL AND RESORCINOL ADJUSTING THE CONCENTRATIONS AND TEMPERATURE TO PRODUCE A VISUALLY TURBID DISPERSION, THE HYDROXYLATED PARENTERALLY ACCEPTABALE PRESERVATIVE BEING IN HIGHER CONCENTRATION THAN NORMALLY REQUIRED FOR PRESERVATIVE ACTION BUT WITHIN PARENTERALLY ACCEPTABLE CONCENTRATIONS, COMPLEXING FINELY DIVIDED SOLID PARENTERALLY USEFUL DRUG WITH THE TURBID DISPERSION TO FOR A SUSPENSION OF STABLE FLOCS OF THE COMPLEXED DRUG AND REACTION PRODUCT OF THE NONIONIC SURFACE ACTIVE AGENT AND PARENTERALLY ACCEPTABLE PRESERVATIVE, SAID SUSPENSION BEING ADAPTED FOR HYPODERMIC INJECTION THROUGH THE HYPERDERMIC NEEDLE OF THE SYRINGE AFTER BEING BROUGHT UP TO FINAL DESIRED VOLUME BY WATER FOR INJECTION, AND BEING WITHOUT SERIOUS STICKING OF THE FLOCS TO THE BARREL OF THE SYRINGE NEEDLE.