Poly-nu-alkylated neomycins, kanamycins and paromomycins

Claim 1

POLY-N-LOWER ALKYL DERIVATIVES OF THE ANTIBIOTICS, NEOMYCIN, KANAMYCIN OR PAROMOMYCIN, HAVING HYPOCHOLESTEROLEMIC ACTIVITY, THE NONTOXIC SALTS OF SAID DERIVATIVES WITH PHARMACEUTICALLY ACCEPTABLE ACIDS OR THE PHARMACEUTICALLY ACCEPTABLE QUATERNARY SALTS OF SAID DERIVATIVES WITH LOWER ALKYL CHLORIDE, BROMIDE OR IODIDES, THE SAID POLY-N-LOWER ALKYL GROUPS OF SAID DERIVATIVES: (1) BEING (A) LOWER ALKYL OF 1-5 CARBON ATOMS; (B) (HYDROXYPHENYL)-LOWER ALKYL, (ALKOXYPHENYL)-LOWER ALKYL, (TRIFLUOROMETHYLPHENYL)-LOWER ALKYL, (AMINOPHENYL)-LOWER ALKYL, (ALKYLAMINOPHENYL)-LOWER ALKKYL, (DIALKYLAMINOPHENYL)-LOWER ALKYL OR PHENYLLOWER ALKYL SAID ALKOXY AND ALKYL GROUPS HAVING 1-5 CARBON ATOMS AND SAID LOWER ALKYL GROUPS HAVING FROM 1 TO 5 CARBON ATOMS; OR (C) HYDROXYLOWER ALKYL, ALKOXYLOWER ALKYL, PHENOXYLOWER ALKYL, AMINOLOWER ALKYL, (ALKYLAMINO)-LOWER ALKYL OR (DIALKYLAMINO)-LOWER ALKYL, SAID ALKOXY OR ALKYL GROUPS HAVING 1-5 CARBON ATOMS AND SAID LOWER ALKYL GROUPS HAVING 2-5 CARBON ATOMS; (2) BEING SUBSTITUTED ON AT LEAST TWO OF THE AMINE FUNCTIONS OF THE AMINO SUGAR NUCLEUS OF THE PARENT ANTIBIOTIC; AND (3) BEING SUFFICIENT IN NUMBER TO DESTROY ANY USEFUL ANTIBIOTIC ACTIVITY OF THE PARENT ANTIBIOTIC COMPOUND.