Patent US3344029A successfully refreshed from Google Patents.
US3344029A
Expired / Lapsed
US
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Sustained release composition
Assignee: U S Ethicals Inc
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Filing: 1963-06-03
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Granted: 1967-09-26
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Expires: 1983-06-03
Abstract
No abstract record available.
Inventors
- 👤 Howard H Berger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:37
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5084; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
184 words
A SUSTAINED ACTION THERAPEUTIC PREPARATION COMPRISING A DOSAGE UNIT CONTAINING A PLURALITY OF RESILIENT CORES EACH CONSISTING ESSENTIALY OF A COHESIVE INTIMATE ADMIXTURE OF A FINELY DIVIDED THERAPEUTICALLY ACTIVE MATERIAL IN POWDER FORM AND AN INGESTIBLE MATERIAL RESISTANT TO DISINTEGRATION IN THE GASTRO-INTESTINAL TACT, THE PROPORTION OF INGESTIBLE MATERIAL TO THERAPEUTICALLY ACTIVE MATERIAL IN EACH CORE VARYING FROM 0.1 TO 2.0:1 AND THERE BEING SOME VARIATION IN PROPORTION AMONG THE CORES TO PROVIDE VARYING RELEASE RATES IN THE GASTRO-INTESTINAL TRACT, AT LEAST A MINOR PROPORTION OF THE CORES BEING COATED, THE COATED CORES HAVING ALTERNATING COATINGS OF THERAPEUTICALLY ACTIVE MATERIAL AND INGESTIBLE MATERIAL, AND THE PROPORTION OF THERAPEUTICALLY ACTIVE MATERIAL AND INGESTIBLE MATERIAL IN THE CORES AND THE AMOUNT OF THERAPEUTICALLY ACTIVE MATERIAL IN THE SUM OF THE COATINGS BEING SO CORRELATED THAT THE PERCENT OF THERAPEUTICALLY ACTIVE MATERIAL IN THE COATINGS PLUS THE PERCENT OF THERAPEUTICALLY ACTIVE MATERIAL IN THE CORES RELEASED DURING THE FIRST HOUR IN THE GASTRO-INTESTINAL TRACT IN THE EVENT OF ACCIDENTAL CRUSHING DURING ORAL ADMINISTRATION IS LESS THAN 50% OF THE TOTAL THERAPEUTIFALLY ACTIVE CONTENT OF THE DOSAGE UNIT.
Claim 2
Dependent Claim
184 words
A SUSTAINED ACTION THERAPEUTIC PREPARATION COMPRISING A DOSAGE UNIT CONTAINING A PLURALITY OF RESILIENT CORES EACH CONSISTING ESSENTIALY OF A COHESIVE INTIMATE ADMIXTURE OF A FINELY DIVIDED THERAPEUTICALLY ACTIVE MATERIAL IN POWDER FORM AND AN INGESTIBLE MATERIAL RESISTANT TO DISINTEGRATION IN THE GASTRO-INTESTINAL TACT, THE PROPORTION OF INGESTIBLE MATERIAL TO THERAPEUTICALLY ACTIVE MATERIAL IN EACH CORE VARYING FROM 0.1 TO 2.0:1 AND THERE BEING SOME VARIATION IN PROPORTION AMONG THE CORES TO PROVIDE VARYING RELEASE RATES IN THE GASTRO-INTESTINAL TRACT, AT LEAST A MINOR PROPORTION OF THE CORES BEING COATED, THE COATED CORES HAVING ALTERNATING COATINGS OF THERAPEUTICALLY ACTIVE MATERIAL AND INGESTIBLE MATERIAL, AND THE PROPORTION OF THERAPEUTICALLY ACTIVE MATERIAL AND INGESTIBLE MATERIAL IN THE CORES AND THE AMOUNT OF THERAPEUTICALLY ACTIVE MATERIAL IN THE SUM OF THE COATINGS BEING SO CORRELATED THAT THE PERCENT OF THERAPEUTICALLY ACTIVE MATERIAL IN THE COATINGS PLUS THE PERCENT OF THERAPEUTICALLY ACTIVE MATERIAL IN THE CORES RELEASED DURING THE FIRST HOUR IN THE GASTRO-INTESTINAL TRACT IN THE EVENT OF ACCIDENTAL CRUSHING DURING ORAL ADMINISTRATION IS LESS THAN 50% OF THE TOTAL THERAPEUTIFALLY ACTIVE CONTENT OF THE DOSAGE UNIT.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1970-09-25 | 1971-03-27 | 1971-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1974-09-25 | 1975-03-27 | 1975-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1978-09-25 | 1979-03-27 | 1979-09-26 | $7700.00 | Window Closed / Lapsed |