Substituted 1, 3, 8-triaza-spiro (4, 5) decanes

Claim 1

CHEMICAL COMPOUNDS SELECTED FROM THE GROUP CONSISTING OF 1 - R1 -2- R1 -3-R3-4-OXO-8R4-1,3,8-TRIAZA-SPIRO (4,5) DECANE AND THE THERAPEUTICALLY ACITVE NONTOXIC ACID ADDITION SALTS THEREOF WHEREIN R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF PHENYL, LOWER ALKARYL,LOWER ALKYL, LOWER ALKOXYPHENYL, CYCLOBUTYL, CYCLOPENTYL, CYCLOHEXYL, AND HALOPHENYL; R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL; R3 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HYDROXYMETHYL, LOWER ALKYL, LOWER ALKYLCARBONYL, CYANOETHYL, LOWER ALKOXYMETHYL, LOWER ALKOXYCARBONYL-LOWER ALKYL, CARBAMOYL LOWER ALKYL, CYCLOPROPYLCARBONYL, BENZYL AND BENZOYL; R4 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF (R''")(R"")CH- AND Z(CH2)N-, WHEREIN R''" IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF METHYL AND ETHYL, R''" IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ARYL, ARYLMETHYLENE AND ARYLETHYLENE, N IS A POSITIVE INTEGER FROM 1 TO 5 AND Z IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, HYDROXY, HYDROXY-LOWER ALKOXY, PHENYL, DIPHENYL-CYANOMETHYLENE, DIARY-HYDROXYMETHYLENE, DIPHENYLPROPIONYLMETHYLENE, FLUOROPHENYL-HYDROXYMETHYLENE, ARYLOXY, 1,4BENZOIDIONXANYL, HALO - 1,4 - BENZODIOXANYL, THIENYL, HALOPHENYL, LOWER ALKYLPHENYL, PYRIDYL, DI-LOWER ALKYLPHENYL, PHENYL-LOWER ALKYLENE, LOWER ALKOXYPHENYL, CYCLOPROPYLETHENYL, BENZOY, HALOBENZOYL, THIENOLYL LOWER ALKYLBENZOYL, LOWER ALKOXYBENZOYL, BENZOYLOXY, BENZYLOXY, PHENYLMETHOXYMETHYLENE, PHENYLHYDROXYMETHYLENE, FLUROROPHENYLLOWER ALKYLCARBONYL-OXY-METHYLENE, FLUOROPHENYL LOWER ALKYLENE, ARYL-LOWER ALKYL ARYL-CYCLOPROPYL, ARYLTHIO, (ARYL) (R'')CH-, WHEREIN R'' IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL, ARYL AND ARYL-LOWER ALKYL, (ARYL)2CH-O-, (LOWER ALKYL)2C=CH-, (ARYL) (R")C=CH-, WHEREIN R" IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWERALKYL, ARYL AND ARYL-LOWER ALKYL; SAID LOWER ALKYL AND LOWER ALKOXY CONTAINING FROM 1 TO 6 CARBON ATOMS AND SAID ARYL BEING A MEMBER SELECTED FROM THE GROUP CONSISTING OF PHENYL, HALOPHENYL, LOWER ALKYLPHENYL, LOWER ALKOXYPHENYL, TRIFLUOROMETHYLPHENYL AND 2-THIENYL. 3. 1-PHENYL-4-OXO-8-(4-OXO-4-(2-THIENYL)-BUTYL)-1,3,8TRIAZA-SPIRO(4,5)DECANE.