Patent US2876238A successfully refreshed from Google Patents.
US2876238A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Purification process for 9alpha-fluorohydrocortisone compounds
Assignee: Merck and Co Inc
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Filing: 1956-12-07
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Granted: 1959-03-03
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Expires: 1976-12-07
Abstract
No abstract record available.
Inventors
- 👤 Robert P Graber
- 👤 Jr Calvin Stewart Snoddy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:24
CPC Classifications
C; C07; C07J; C07J5/00; C07J75/00
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
136 words
A PROCESS FOR PURIFYING A CRUDE MIXTURE CONTAINING A 9A-FLUOROHYDROCORTISONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF 9A-FLUOROHYDROCORTISONE AND 21ACYLOXY DERIVATIVES THEREOF, WHEREIN THE ACYL GROUP IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID CONTAINING FROM ONE TO EIGHT CARBON ATOMS, AND A $4.3(14)-PREGNADIENE11, 17A,21-TRIOL-3,20-DIONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF $4,3(14)-PREGNADIENE-11,17A,21-TRIOL-3, 20-DIONE AND 21-ACYLOXY DERIVATIVES THEREOF, WHEREIN THE ACYL GROUP IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID CONTAINING FROM ONE TO EIGHT CARBON ATOMS, WHICH COMPRISES: TREATING THE CRUDE MIXTURE WITH AN ACYLATING AGENT CONTAINING THE ACYL RESIDUE OF AN ORGANIC CARBOXYLIC ACID CONTAINING FROM ONE TO EIGHT CARBON ATOMS, SEPARATING THE UNUSED ACYLATING AGENT FROM THE RESULTING MIXTURE CONTAINING UNREACTED 9A-FLUOROHYDROCORTISONE COMPOUND AND THE 11-ACYLOXY DERIVATIVE OF THE $4,3(14)-PREGNADIENE11,17A,21-TRIOL-3,20-DIONE COMPOUND, AND CRYSTALLIZING THE 9A-FLUOROHYDROCORTISONE COMPOUND FROM THE RESULTING MIXTURE CONTAINING THE ACYLATED $4,3(14)-PREGNADIENE11,7A,21-TRIOL-3,20-DIONE COMPOUND.
Claim 2
Dependent Claim
136 words
A PROCESS FOR PURIFYING A CRUDE MIXTURE CONTAINING A 9A-FLUOROHYDROCORTISONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF 9A-FLUOROHYDROCORTISONE AND 21ACYLOXY DERIVATIVES THEREOF, WHEREIN THE ACYL GROUP IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID CONTAINING FROM ONE TO EIGHT CARBON ATOMS, AND A $4.3(14)-PREGNADIENE11, 17A,21-TRIOL-3,20-DIONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF $4,3(14)-PREGNADIENE-11,17A,21-TRIOL-3, 20-DIONE AND 21-ACYLOXY DERIVATIVES THEREOF, WHEREIN THE ACYL GROUP IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID CONTAINING FROM ONE TO EIGHT CARBON ATOMS, WHICH COMPRISES: TREATING THE CRUDE MIXTURE WITH AN ACYLATING AGENT CONTAINING THE ACYL RESIDUE OF AN ORGANIC CARBOXYLIC ACID CONTAINING FROM ONE TO EIGHT CARBON ATOMS, SEPARATING THE UNUSED ACYLATING AGENT FROM THE RESULTING MIXTURE CONTAINING UNREACTED 9A-FLUOROHYDROCORTISONE COMPOUND AND THE 11-ACYLOXY DERIVATIVE OF THE $4,3(14)-PREGNADIENE11,17A,21-TRIOL-3,20-DIONE COMPOUND, AND CRYSTALLIZING THE 9A-FLUOROHYDROCORTISONE COMPOUND FROM THE RESULTING MIXTURE CONTAINING THE ACYLATED $4,3(14)-PREGNADIENE11,7A,21-TRIOL-3,20-DIONE COMPOUND.
References Cited (Backward Citations)
US2749356A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1962-03-02 | 1962-09-01 | 1963-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1966-03-02 | 1966-09-01 | 1967-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1970-03-02 | 1970-09-01 | 1971-03-03 | $7700.00 | Window Closed / Lapsed |