Ferrous carboxymethyl dextran

Claim 1

A METHOD FOR PRODUCING A FERROUS CARBOXYMETHYL DEXTRAN COMPLEX WHICH IS INSOLUBLE IN AQUEOUS ACID SOLUTION BUT READILY SOLUBLE IN AQUEOUS ALKALINE SOLUTION AT PH 8.0 TO 8.5, COMPRISING SLOWLY ADDING AN AQUEOUS DISPERSION OF A CARBOXYMETHYL ETHER OF WATER-DISPERSIBLE DEXTRAN HAVING A MOLECULAR WEIGHT BETWEEN 200 AND THAT OF NATIVE, UNHYDROLYZED, MICROBIOOGICALLY PRODUCED DEXTRAN CONTAINING AN AVERAGE OF ABOUT 1.0 TO 3.0 CARBOXYMETHYL GROUPS PER ANHYDROGLUCOSE UNIT, WHICH DISPERSION HAS THE CONSTITUENCY OF A JELLY, TO AN AQUEOUS SOLUTION OF FERROUS CHOLORIDE WITH VIGOROUS STIRRING AND THE PASSAGE OF CARBON DIOXIDE HAS THROUGH THE REACTION MEDIUM TO INHIBIT OXIDATION OF FERROUS ION, THE RELATIVE PROPORTIONS BY WEIGHT OF THE CARBOXYMETHYL DEXTRAN AND FERROUS CHLORIDE BEING FROM 1:5 TO 1:10, HOLDING THE RESULTING FLUID MASS AT ROOM TEMPERATURE UNTIL A GELATINOUS PRECIPATE COMPRISING THE FERROUS COMPLEX FORMS AND SETTLES, SEPARATING THE GELATINOUS PRECIPATE FROM THE SUPERNATANT, REPRECIPITATING THE COMPLEX BY MIXING THE GELATINOUS PRECIPITATE WITH METHANOL WITH VIGOROUS STIRRING, SEPARATING THE PRECIPITATE, AND REPEATING THE REPRECIPITATION FROM METHANOL UNTIL THE SUPERNATANT IS SUBSTANTIALLY COLORLESS AND A BROWN COLORED FERROUS CARBOXYMETHYL DEXTRAN COMPLEX IS OBTAINED IN GRANULAR CONDITION.

Claim 2

A METHOD FOR PRODUCING A FERROUS CARBOXYMETHYL DEXTRAN COMPLEX WHICH IS INSOLUBLE IN AQUEOUS ACID SOLUTION BUT READILY SOLUBLE IN AQUEOUS ALKALINE SOLUTION AT PH 8.0 TO 8.5, COMPRISING SLOWLY ADDING AN AQUEOUS DISPERSION OF A CARBOXYMETHYL ETHER OF WATER-DISPERSIBLE DEXTRAN HAVING A MOLECULAR WEIGHT BETWEEN 200 AND THAT OF NATIVE, UNHYDROLYZED, MICROBIOOGICALLY PRODUCED DEXTRAN CONTAINING AN AVERAGE OF ABOUT 1.0 TO 3.0 CARBOXYMETHYL GROUPS PER ANHYDROGLUCOSE UNIT, WHICH DISPERSION HAS THE CONSTITUENCY OF A JELLY, TO AN AQUEOUS SOLUTION OF FERROUS CHOLORIDE WITH VIGOROUS STIRRING AND THE PASSAGE OF CARBON DIOXIDE HAS THROUGH THE REACTION MEDIUM TO INHIBIT OXIDATION OF FERROUS ION, THE RELATIVE PROPORTIONS BY WEIGHT OF THE CARBOXYMETHYL DEXTRAN AND FERROUS CHLORIDE BEING FROM 1:5 TO 1:10, HOLDING THE RESULTING FLUID MASS AT ROOM TEMPERATURE UNTIL A GELATINOUS PRECIPATE COMPRISING THE FERROUS COMPLEX FORMS AND SETTLES, SEPARATING THE GELATINOUS PRECIPATE FROM THE SUPERNATANT, REPRECIPITATING THE COMPLEX BY MIXING THE GELATINOUS PRECIPITATE WITH METHANOL WITH VIGOROUS STIRRING, SEPARATING THE PRECIPITATE, AND REPEATING THE REPRECIPITATION FROM METHANOL UNTIL THE SUPERNATANT IS SUBSTANTIALLY COLORLESS AND A BROWN COLORED FERROUS CARBOXYMETHYL DEXTRAN COMPLEX IS OBTAINED IN GRANULAR CONDITION.