Patent US2528972A successfully refreshed from Google Patents.
US2528972A
Expired / Lapsed
US
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Prophylactic toxoid compound and method of making same
Assignee: WESTERN RESERVE UNIVERSITY
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Filing: 1947-05-15
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Granted: 1950-11-07
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Expires: 1967-05-15
Abstract
No abstract record available.
Inventors
- 👤 Pillemer Louis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:21
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
161 words
THE METHOD OF PRODUCING A STERILE, STABLE, NON-ALLERGENIC, NON-ANAPHYLACTOGENIC PRODUCT COMPRISING TOXOID FROM CRUDE BACTERIAL CULTURE CONTAINING SAID TOXOID WHICH INCLUDES THE STEP OF SEPARATING SAID TOXOID FROM A SOLUTION IN WATER THEREOF AND OF THE ALLERGENIC AND ANAPHYLACTOGENIC CONSTITUENTS OF SAID CRUDE CULTURE BY ADDING TO SAID SOLUTION AN ALCOHOL OF THE GROUP CONSISTING OF METHANOL AND ETHANOL AND ADJUSTING SAID SOLUTION TO THE MINIMUM SOLUBILITY POINT OF SAID TOXOID BY CONTROLLING THE CONCENTRATION OF SAID ALCOHOL AT FROM 25% TO 50% AND THE PH AT FROM 4 TO 5, WHILE MAINTAINING THE TEMPERATURE BELOW THE CRITICAL POINT OF PROTEIN DENATURATION AT FROM-3*C. TO THE FREEZING POINT OF THE SOLUTION, SEPARATING THE RESULTING PRECIPITATE OF SAID TOXOID FROM THE SUPERNATANT, PREPARING A SOLUTION OF SAID PRECIPITATED TOXOID IN A WATER SOLUTION OF NON-TOXIC, NON-ALLERGENIC, NON-ANAPHYLACTOGENIC DIPOLAR IONS DERIVED FROM AMINO ACIDS OF THE GROUP CONSISTING OF GLYCINE, TAURINE, LEUCINE AND ALANINE AND FILTERING THE SOLUTION THROUGH A STERILE BACTERIOLOGICAL FILTER.
Claim 2
Independent Claim
161 words
THE METHOD OF PRODUCING A STERILE, STABLE, NON-ALLERGENIC, NON-ANAPHYLACTOGENIC PRODUCT COMPRISING TOXOID FROM CRUDE BACTERIAL CULTURE CONTAINING SAID TOXOID WHICH INCLUDES THE STEP OF SEPARATING SAID TOXOID FROM A SOLUTION IN WATER THEREOF AND OF THE ALLERGENIC AND ANAPHYLACTOGENIC CONSTITUENTS OF SAID CRUDE CULTURE BY ADDING TO SAID SOLUTION AN ALCOHOL OF THE GROUP CONSISTING OF METHANOL AND ETHANOL AND ADJUSTING SAID SOLUTION TO THE MINIMUM SOLUBILITY POINT OF SAID TOXOID BY CONTROLLING THE CONCENTRATION OF SAID ALCOHOL AT FROM 25% TO 50% AND THE PH AT FROM 4 TO 5, WHILE MAINTAINING THE TEMPERATURE BELOW THE CRITICAL POINT OF PROTEIN DENATURATION AT FROM-3*C. TO THE FREEZING POINT OF THE SOLUTION, SEPARATING THE RESULTING PRECIPITATE OF SAID TOXOID FROM THE SUPERNATANT, PREPARING A SOLUTION OF SAID PRECIPITATED TOXOID IN A WATER SOLUTION OF NON-TOXIC, NON-ALLERGENIC, NON-ANAPHYLACTOGENIC DIPOLAR IONS DERIVED FROM AMINO ACIDS OF THE GROUP CONSISTING OF GLYCINE, TAURINE, LEUCINE AND ALANINE AND FILTERING THE SOLUTION THROUGH A STERILE BACTERIOLOGICAL FILTER.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1953-11-06 | 1954-05-08 | 1954-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1957-11-06 | 1958-05-08 | 1958-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1961-11-06 | 1962-05-08 | 1962-11-07 | $7700.00 | Window Closed / Lapsed |