Method for production of 7-chloro-4-aminoquinolines

Claim 1

IN A METHOD OF PRODUCING A COMPOUND SUITABLE FOR CONVERSION INTO AN INTERMEDIATE FOR PRODUCTION OF AN ANTIMALARIAL DRUG OF THE 7-CHLORO4-AMINOQUINOLINE TYPE, WHICH METHOD INCLUDES HEATING A MIXTURE OF 1 MOL OF DIETHYL MALONATE, 0.993 MOL OF N,N''-DI-(M-CHLOROPHENYL) FORMANIDINE AND 105 PARTS OF BENZENE, AT 100*C. TO 105* C. FOR SUBSTANTIALLY SIXTEEN HOURS, DILUTING THE RESULTING REACTION MASS WITH SUBSTANTIALLY 1470 PARTS OF BENZENE, ADDING TO THE DILUTED MASS 136 PARTS OF 20* BE. HYDROCHLORIC ACID, THE IMPROVEMENT WHICH COMPRISES REFLUXING THE RESULTING MATERIAL UNTIL THE BENZENE IS FREED FROM WATER, COOLING THE RESULTING DEHYDRATED MIXTURE, FILTERING THE MIXTURE TO OBTAIN A FILTER CAKE COMPOSED OF THE HYDROCHLORIDES OF M-CHLORANILINE AND OF N,N''-DI-(M-CHLOROPHENYL)FORMAMIDINE, AND A FILTRATE, WASHING THE FILTER CAKE WITH BENZENE, AND COMBINING THE FILTRATE AND THE BENEZENE WASHINGS.