Aldose reductase inhibitor

Abstract

Abstract PURPOSE:To obtain the titled inhibitor containing a specific chalcone derivative as an ingredient and useful in prevention or remedy for various kind of complications in diabetes such as cataract, retinopathy, nerve disorder or renal disease. CONSTITUTION:A compound expressed by the formula (X and Y are H or a bond hand together; R1 is H, acetoxy, carboxymethoxy or methoxycarbonylmethoxy; R2 is isoprenyl, isopentyl, n-propyl or H; R3 is OH or methoxy; R4 and R5 are H, OH or methoxy provided that when R5 is OH, R1 and R3 are OH and R2 is H and when R1 is OH and R2 is isopentyl, R3 is OH and R5 is H, etc.), e.g. 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-1- propanone is contained as an active ingredient. The above-mentioned compound is administered in doses of 60-500mg three times daily as oral agent and in doses of 1-30mg daily as parenteral agent.

Inventors

• 👤 Masao Chin
• 👤 Shunji Sato
• 👤 Kunio Hosaka
• 👤 Hiroshi Mihashi

Bibliographic Details