Production of granular porous chitosan

Abstract

Abstract PURPOSE:To obtain porous granular chitosan having uniform particle size, and uniform fine pores on the surface of the sphere or the broken surface, and suitable as a stationary phase of chromatography, by preparing a concentrated chitosan solution from a chitosan having low molecular weight, and dripping the solution into a basic solution to effect the coagulation of the chitosan solution. CONSTITUTION:A low-molecular weight chitosan having an average molecular weight of 10,000-230,000 is dissolved in an acidic aqueous solution (e.g. aqueous solution of acetic acid, dichloroacetic acid, etc.) to a concentration of 2-20wt%, and the solution is dripped into a basic solution composed of a basic substance (e.g. NaOH, ammonia, etc.) and water and/or an alcohol (e.g. methanol, ethanol, etc.). The obtained spherical coagulum is washed with water and dried to obtain the objective product.

Inventors

• 👤 Yoshihide Kawamura
• 👤 佳秀 川村
• 👤 Hiroaki Yabe
• 👤 谷邊　博昭
• 👤 Itsuo Kurahashi
• 👤 倉橋　五男
• 👤 Hiroshi Seo
• 👤 瀬尾　寛
• 👤 Saburo Nakajima
• 👤 三郎 中島

Bibliographic Details