Modified antigen, its preparation and preventive and remedy for allergic disease containing the same

Abstract

Abstract PURPOSE:To provide a modified antigen composed of a polymer of an aspartic acid derivative bonded chemically to an antigen causing allergic diseases, and useful as a preventive and remedy for allergic diseases. CONSTITUTION:The compound of formula I (R1 is hydroxyalkyl; R2 is aminoalkyl; R is R1 or R2; n and n' are number of residues bonded to beta-position; m and m' are number of residues bonded to alpha-position; n+n'+m+m' is 6-3,000; n'+m' is 0-1,500) is bonded to an antigen by covalent bond directly or indirectly with 2,4,6-trichloro-S-triazine, 2,4-dichloro-6-methoxy-S-triazine, etc. The compound of formula I can be prepared by reacting the anhydropolyaspartic acid of formula II with the compound of formula NH2-R1 and NH2-R2. The antigen is e.g. hapten, respiratory antigen, alimentary antigen, enzymatic preparation, biological preparation, product from genetic operation, etc.

Inventors

• 👤 Takuo Aoyama
• 👤 青山　卓夫
• 👤 Aritsune Katsuhata
• 👤 勝畑　有恒
• 👤 Hidenori Maeda
• 👤 英則 前田
• 👤 Toru Ando
• 👤 徹 安藤

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