Sustained release composition

Abstract

Abstract PURPOSE:A sustained release composition obtained by adding a specific amount of a hardended oil to a sustained release composition containing a water-soluble active component. CONSTITUTION:A water-soluble active component (e.g., diltiazem hydrochloride, diclofenac sodium, tiaramide hydrochloride, etc.) is belended with an excipient (e.g., lactose, mannose, galactose, fructose, etc.), and the blend is mixed with 10-80wt% hardened oil based on the total amount of preparation. The mixture is kneaded sufficiently with a binder (e.g., aqueous solution of hydroxypropyl cellulose, carboxymethylcelluose, methyl celluose, etc.), filtered, dried, granulated uniformly, and blended with a lubricant (e.g., magnesium stearate, calcium stearate, etc.), to give sustained release composition.

Inventors

• 👤 Masamitsu Shinoda
• 👤 篠田　雅充
• 👤 Giichi Ikeda
• 👤 池田　義一

Bibliographic Details