Pyridazinone derivative

Abstract

Abstract NEW MATERIAL:A compound shown by the formula 1 (R<1> is H, formyl, alkanoyl, etc.; R<2> is H, or alkyl). EXAMPLE:5-Methyl-6-(4-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-4,5-dihydro -3(2H)-pyr idazinone. USE:Useful as a drug for a circulatory organ system such as hypotensor, antithrombosis, cardiac, etc. Having increasing action on contraction ability of cardiac muscle, inhibitory action on blood platelet aggregation, etc. PROCESS:A compound shown by the formula 2 (Z is OH, etc.) is reacted with a compound shown by the formula 3 in a solvent such as benzene, etc. at room temperature -200 deg.C to give a compound shown by the formula 4. The prepared reaction product is reacted in polyphosphoric acid or sulfuric acid at room temperature -250 deg.C to give a compound shown by the formula 5, which is reacted with acetic acid, acetic anhydride, etc. in a solvent such as benzene, etc. at room temperature, and, if necessary, cooled or heated, to give a compound shown by the formula 1.

Inventors

• 👤 Isao Kataue
• 👤 片上　功
• 👤 Akira Matsubara
• 👤 松原　章
• 👤 Takashi Nishina
• 👤 仁科　孝士
• 👤 Joji Kamiya
• 👤 神谷　譲二
• 👤 Yasuhito Tanaka
• 👤 康仁 田中
• 👤 Akira Awaya
• 👤 昭 粟屋

Bibliographic Details