Pharmaceutical preparation

Abstract

Abstract PURPOSE:To provide a pharmaceutical preparation for transcutaneous administration, having excellent antiarrhythmic activity, and composed of a backing member and a drug-containing substrate layer applied to a surface of said backing member, wherein said substrate layer contains a self-adhesive polymer and propranolol as essential components. CONSTITUTION:The objective pharmaceutical preparation for transcutaneous administration is composed of (A) a backing member having sufficiently high flexibility and stretchability to follow the expansion and contraction of the surface of the applied body (e.g. film or sheet of polyolefin, polyurethane, etc.) and (B) a drug-containing substrate layer containing (a) a polymer having a glass transition temperature (Tg) of -70--10 deg.C and exhibiting pressure-sensitive adhesivity at normal temperature and (b) propranolol as essential components. The preparation may contain an absorption assistant, a dissolution promoting agent, etc. (e.g. glycerol, lanoline, etc.). The pharmaceutical preparation exhibits high harmacological effect by releasing the effective amount of propranolol uniformly and continuously to the body through the skin.

Inventors

• 👤 Shoichi Tokuda
• 👤 祥一 徳田
• 👤 Yusuke Ito
• 👤 祐輔 伊藤
• 👤 Saburo Otsuka
• 👤 大塚　三郎
• 👤 Toshiyuki Yoshikawa
• 👤 利之 吉川

Bibliographic Details